16
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Food addiction and obesity: unnecessary medicalization of hedonic overeating

      Nature Reviews Endocrinology
      Springer Nature

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The concept of food addiction as an explanation for the rise in obesity has become increasingly popular. In this Opinion article, Graham Finlayson critically evaluates the food addiction hypothesis and highlights several problems with its use.

          Related collections

          Most cited references73

          • Record: found
          • Abstract: not found
          • Book: not found

          Diagnostic and Statistical Manual of Mental Disorders

            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            The global obesity pandemic: shaped by global drivers and local environments

            The Lancet, 378(9793), 804-814
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Addiction-like reward dysfunction and compulsive eating in obese rats: Role for dopamine D2 receptors

              We found that development of obesity was coupled with the emergence of a progressively worsening brain reward deficit. Similar changes in reward homeostasis induced by cocaine or heroin is considered a critical trigger in the transition from casual to compulsive drug-taking. Accordingly, we detected compulsive-like feeding behavior in obese but not lean rats, measured as palatable food consumption that was resistant to disruption by an aversive conditioned stimulus. Striatal dopamine D2 receptors (D2R) were downregulated in obese rats, similar to previous reports in human drug addicts. Moreover, lentivirus-mediated knockdown of striatal D2R rapidly accelerated the development of addiction-like reward deficits and the onset of compulsive-like food seeking in rats with extended access to palatable high-fat food. These data demonstrate that overconsumption of palatable food triggers addiction-like neuroadaptive responses in brain reward circuitries and drives the development of compulsive eating. Common hedonic mechanisms may therefore underlie obesity and drug addiction.
                Bookmark

                Author and article information

                Journal
                Nature Reviews Endocrinology
                Nat Rev Endocrinol
                Springer Nature
                1759-5029
                1759-5037
                May 26 2017
                May 26 2017
                :
                :
                Article
                10.1038/nrendo.2017.61
                28549063
                8668525a-81c7-4ac4-a07f-0ed497785360
                © 2017
                History

                Comments

                Comment on this article