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Polymorphisms associated with cholesterol and risk of cardiovascular events.
Sekar Kathiresan
1 ,
Olle Melander ,
Dragi Anevski ,
Candace Guiducci ,
Noël P Burtt ,
Charlotta Roos ,
Joel N Hirschhorn ,
Göran Berglund ,
Bo Hedblad ,
Leif Groop ,
David M Altshuler ,
Christopher Newton-Cheh ,
Marju Orho-Melander
Mar 20 2008
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Abstract
Common single-nucleotide polymorphisms (SNPs) that are associated with blood low-density lipoprotein (LDL) or high-density lipoprotein (HDL) cholesterol modestly affect lipid levels. We tested the hypothesis that a combination of such SNPs contributes to the risk of cardiovascular disease.