7
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Relation between adenosine and T-helper 1/T-helper 2 imbalance in women with preeclampsia.

      Obstetrics and gynecology
      Adenosine, blood, Adult, CD4-Positive T-Lymphocytes, secretion, Female, Humans, In Vitro Techniques, Interferon-gamma, Interleukin-1, Interleukin-2, Interleukin-4, Pre-Eclampsia, Pregnancy, Purinergic P1 Receptor Antagonists, Theophylline, analogs & derivatives, pharmacology

      Read this article at

      ScienceOpenPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          To evaluate the relationship between changes in plasma adenosine concentration and imbalances in the T-helper 1/T-helper 2 ratio in peripheral blood of women with preeclampsia. Plasma adenosine concentrations and the T-helper 1/T-helper 2 ratio were examined in the peripheral blood of 16 preeclamptic and normal pregnant women. The proportion of specific T-cell marker CD4-positive cells expressing intracellular cytokines, interferon-gamma derived from T-helper 1 and interleukin-4 derived from T-helper 2 cells, were analyzed by flow cytometry. The ratio of interferon-gamma secreting cells to interleukin-4 secreting cells was taken as the T-helper 1/T-helper 2 ratio in vivo. The effect of the adenosine-receptor blocker 8-sulfophenyltheophylline was also measured in vitro. Mean plasma adenosine concentration in preeclampsia was significantly higher than that in normal pregnancy (0.68 +/- 0.07 micromol/L versus 0.39 +/- 0.06 micromol/L, P <.05). The proportions of interferon-gamma secreting cells increased and interleukin-4 secreting cells decreased significantly in preeclampsia, and the T-helper 1/T-helper 2 ratio in preeclampsia was significantly higher than in normal pregnancy (18.1 +/- 2.6 versus 9.9 +/- 1.5, P <.05). The increase of the proportion of interferon-gamma secreting cells after adenosine receptor blockade in preeclampsia significantly exceeded that of normal pregnancy. The T-helper 1/T-helper 2 ratio in preeclampsia was significantly greater than that in normal pregnancy (36% versus 17%, P <.05). Increased plasma adenosine may be involved in the regulation of imbalances in the T-helper 1/T-helper 2 ratio in women with preeclampsia.

          Related collections

          Author and article information

          Comments

          Comment on this article