+1 Recommend
1 collections
      • Record: found
      • Abstract: found
      • Article: found

      Effect of L-Carnitine and Palmitoyl- L-Carnitine on Erythroid Colony Formation in Fetal Mouse Liver Cell Culture

      Read this article at

          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.


          The administration of L-carnitine to patients undergoing hemodialysis increases hematocrit and improves the response to recombinant human erythropoietin (rhEPO). This suggests a contribution by carnitine to erythrocyte membrane function or erythropoiesis. We investigated the effect of L-carnitine and palmitoyl- L-carnitine on erythropoiesis by assessing erythroid colony formation in in vitro fetal mouse liver cell cultures. L-Carnitine or palmitoyl- L-carnitine was added with rhEPO to fetal mouse liver cell cultures. Doses of L-carnitine of up to 200 µmol/l to the culture had no effect on colony formation. In contrast, the addition of above 12.5 µmol/l palmitoyl- L-carnitine into the culture increased colony formation significantly. These results suggest that long-chain acyl carnitine may have an effect on erythropoiesis.

          Related collections

          Most cited references 1

          • Record: found
          • Abstract: not found
          • Article: not found

          Effect of L-carnitine and acetyl-L-carnitibe on the human erythrocyte membrane stability and deformability


            Author and article information

            Am J Nephrol
            American Journal of Nephrology
            S. Karger AG
            October 1998
            10 September 1998
            : 18
            : 5
            : 355-358
            Second Department of Internal Medicine, School of Medicine, Kanazawa University, Kanazawa, Japan
            13376 Am J Nephrol 1998;18:355–358
            © 1998 S. Karger AG, Basel

            Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

            Page count
            Figures: 1, Tables: 2, References: 16, Pages: 4
            Self URI (application/pdf):
            Clinical Study


            Comment on this article