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      Cation Transport in Erythrocytes of Patients with Renal Failure

      , , , ,

      Nephron

      S. Karger AG

      Sodium pump, Na+, K+-ATPase, Renal failure, Erythrocyte, Rubidium-86 uptake

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          Abstract

          Na<sup>+</sup>, K<sup>+</sup>-ATPase activity in erythrocytes (RBC) has been assessed indirectly by the <sup>86</sup>Rb uptake method in 10 patients with acute renal failure (ARF), 11 patients with chronic renal failure (CRF) on haemodialysis and 13patients treated by kidney transplantation, and compared to age-matched healthy controls. In each patients, the sensitivity of <sup>86</sup>Rb uptake to digoxin (IC<sub>50</sub>) has been measured. Na<sup>+</sup>, K<sup>+</sup>-ATPase activity was decreased in patients with ARF and in patients with CRF but not in transplanted patients. IC<sub>50</sub> was lowered in transplanted patients. The implications of these findings are discussed in terms of possible mechanisms of the changes in Na<sup>+</sup>, K<sup>+</sup>-ATPase activity in RBC of patients with renal failure.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1982
          1982
          03 December 2008
          : 32
          : 4
          : 347-350
          Affiliations
          Laboratoire B de Pharmacologie, Faculté de Médecine, Vandæuvre-lès-Nancy, France; Service de Néphrologie, Service de Médecine Nucléaire, Nancy, France
          Article
          182877 Nephron 1982;32:347–350
          10.1159/000182877
          6300713
          © 1982 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 4
          Categories
          Original Paper

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