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      Ribosome biogenesis in the yeast Saccharomyces cerevisiae.

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          Abstract

          Ribosomes are highly conserved ribonucleoprotein nanomachines that translate information in the genome to create the proteome in all cells. In yeast these complex particles contain four RNAs (>5400 nucleotides) and 79 different proteins. During the past 25 years, studies in yeast have led the way to understanding how these molecules are assembled into ribosomes in vivo. Assembly begins with transcription of ribosomal RNA in the nucleolus, where the RNA then undergoes complex pathways of folding, coupled with nucleotide modification, removal of spacer sequences, and binding to ribosomal proteins. More than 200 assembly factors and 76 small nucleolar RNAs transiently associate with assembling ribosomes, to enable their accurate and efficient construction. Following export of preribosomes from the nucleus to the cytoplasm, they undergo final stages of maturation before entering the pool of functioning ribosomes. Elaborate mechanisms exist to monitor the formation of correct structural and functional neighborhoods within ribosomes and to destroy preribosomes that fail to assemble properly. Studies of yeast ribosome biogenesis provide useful models for ribosomopathies, diseases in humans that result from failure to properly assemble ribosomes.

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          Author and article information

          Journal
          Genetics
          Genetics
          Oxford University Press (OUP)
          1943-2631
          0016-6731
          Nov 2013
          : 195
          : 3
          Affiliations
          [1 ] Department of Biological Sciences, Center for Nucleic Acids Science and Technology, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213.
          Article
          195/3/643
          10.1534/genetics.113.153197
          3813855
          24190922
          86b137be-900e-4258-9138-b9a306ae61b6
          History

          RNA polymerase I,ribosomal RNA,ribosome,ribosome assembly,snoRNAs

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