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      Corrigendum to “Tumor-Derived CXCL1 Promotes Lung Cancer Growth via Recruitment of Tumor-Associated Neutrophils”

      correction
      Journal of Immunology Research
      Journal of Immunology Research
      Hindawi

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          Abstract

          The article titled “Tumor-Derived CXCL1 Promotes Lung Cancer Growth via Recruitment of Tumor-Associated Neutrophils” [1] was reassessed due to concerns raised with research by Xuetao Cao [2]. The editorial board identified a figure duplication in the top two panels of Figure 4(c), which the authors explained was a mistake introduced during initial manuscript preparation and figure assembly. The experiment was repeated by Dr. Mingyan Huang and supervised by Prof. Nan Li of the National Key Laboratory of Medical Immunology, Second Military Medical University. The corrected Figure 4(c) is shown below.

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          Tumor-Derived CXCL1 Promotes Lung Cancer Growth via Recruitment of Tumor-Associated Neutrophils

          Neutrophils have a traditional role in inflammatory process and act as the first line of defense against infections. Although their contribution to tumorigenesis and progression is still controversial, accumulating evidence recently has demonstrated that tumor-associated neutrophils (TANs) play a key role in multiple aspects of cancer biology. Here, we detected that chemokine CXCL1 was dramatically elevated in serum from 3LL tumor-bearing mice. In vitro, 3LL cells constitutively expressed and secreted higher level of CXCL1. Furthermore, knocking down CXCL1 expression in 3LL cells significantly hindered tumor growth by inhibiting recruitment of neutrophils from peripheral blood into tumor tissues. Additionally, tumor-infiltrated neutrophils expressed higher levels of MPO and Fas/FasL, which may be involved in TAN-mediated inhibition of CD4+ and CD8+ T cells. These results demonstrate that tumor-derived CXCL1 contributes to TANs infiltration in lung cancer which promotes tumor growth.
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            Chinese ministry investigates duplications in papers by university president

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              Author and article information

              Journal
              J Immunol Res
              J Immunol Res
              JIR
              Journal of Immunology Research
              Hindawi
              2314-8861
              2314-7156
              2020
              12 August 2020
              12 August 2020
              : 2020
              : 5106904
              Article
              10.1155/2020/5106904
              7447590
              86bed653-e172-4296-90d0-a4d64df5c0c9
              Copyright © 2020 .

              This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

              History
              : 21 July 2020
              : 22 July 2020
              Categories
              Corrigendum

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