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      EASL Clinical Practice Guidelines: Drug-induced liver injury

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          Abstract

          Idiosyncratic (unpredictable) drug-induced liver injury is one of the most challenging liver disorders faced by hepatologists, because of the myriad of drugs used in clinical practice, available herbs and dietary supplements with hepatotoxic potential, the ability of the condition to present with a variety of clinical and pathological phenotypes and the current absence of specific biomarkers. This makes the diagnosis of drug-induced liver injury an uncertain process, requiring a high degree of awareness of the condition and the careful exclusion of alternative aetiologies of liver disease. Idiosyncratic hepatotoxicity can be severe, leading to a particularly serious variety of acute liver failure for which no effective therapy has yet been developed. These Clinical Practice Guidelines summarize the available evidence on risk factors, diagnosis, management and risk minimization strategies for drug-induced liver jury.

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          Author and article information

          Journal
          Journal of Hepatology
          Journal of Hepatology
          Elsevier BV
          01688278
          March 2019
          March 2019
          Article
          10.1016/j.jhep.2019.02.014
          30926241
          © 2019

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