Nutrient-sensing mechanisms across evolution.

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Abstract

For organisms to coordinate their growth and development with nutrient availability, they must be able to sense nutrient levels in their environment. Here, we review select nutrient-sensing mechanisms in a few diverse organisms. We discuss how these mechanisms reflect the nutrient requirements of specific species and how they have adapted to the emergence of multicellularity in eukaryotes.

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Journal

Journal ID (iso-abbrev): Cell

Title: Cell

ISSN (Electronic): 1097-4172

ISSN (Print): 0092-8674

Publication date (Electronic): Mar 26 2015

Volume: 161

Issue: 1

Affiliations

[1 ] Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Department of Biology, 9 Cambridge Center, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Koch Institute for Integrative Cancer Research, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

[2 ] Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Department of Biology, 9 Cambridge Center, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Koch Institute for Integrative Cancer Research, 77 Massachusetts Avenue, Cambridge, MA 02139, USA. Electronic address: sabatini@wi.mit.edu.

Article

Publisher Item ID: S0092-8674(15)00242-1 Mid ID: NIHMS672161

DOI: 10.1016/j.cell.2015.02.041

PubMed ID: 25815986

SO-VID: 86f8810e-78ad-4eda-93f5-8c291682eb1d

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