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Genetic analysis of the corticosterone response to ethanol in BXD recombinant inbred mice.
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Abstract
The genetic control over the corticosterone response to ethanol (EtOH) and its possible
relationship to other EtOH-related traits was examined using BXD recombinant inbred
(RI) strains derived from an F2 cross of C57BL/6J (B6) and DBA/2J (D2) progenitor
strains. Quantitative trait locus (QTL) analysis of corticosterone levels 1 hr following
EtOH suggested the influence of a single major gene on this trait. Two loci were predicted
to account for 47% of the genetic variance in plasma corticosterone levels 6 hr following
EtOH, whereas 3 loci were predicted to account for 78% of the genetic variance in
corticosterone levels 7 hr following EtOH. Markers associated with corticosterone
levels 7 hr following EtOH and corrected corticosterone levels 6 hr post-EtOH overlapped
with ones found to influence acute and chronic EtOH withdrawal severity, suggesting
some degree of common genetic determination between these traits. Overall these results
indicate that gene action significantly influences stress responsiveness and suggest
possible chromosomal locations of these genes.