[1
]Center for Data Sciences, Brigham and Women’s Hospital, Boston, MA 02115, USA
[2
]Division of Rheumatology and Genetics, Department of Medicine, Brigham and Women’s
Hospital, Boston, MA 02115, USA
[3
]Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115 USA
[4
]Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
[5
]Division of Rheumatology, Immunology, Allergy, Brigham and Women’s Hospital and Harvard
Medical School, MA 02115, USA
[6
]Department of Rheumatology, Barts Health NHS Trust, London, E1 1BB, UK
[7
]Division of Rheumatology, Hospital for Special Surgery, New York, NY 10021, USA
[8
]Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA
[9
]Division of Allergy, Immunology and Rheumatology, Department of Medicine, University
of Rochester Medical Center, Rochester, NY 14642, USA
[10
]Division of Clinical Immunology and Rheumatology, Department of Medicine, University
of Alabama at Birmingham, Birmingham, AL 35294-2182, USA
[11
]Division of Rheumatology, Department of Medicine, University of Massachusetts Medical
School, Worcester, MA 01605, USA
[12
]Arthritis and Tissue Degeneration, Hospital for Special Surgery, New York, NY 10021,
USA
[13
]Department of Medicine, Division of Rheumatology, Allergy and Immunology, University
of California, San Diego, La Jolla, CA 92093 USA
[14
]Division of Rheumatology, Department of Medicine, Northwestern University Feinberg
School of Medicine. Chicago, IL 60611, USA
[15
]Department of Pathology and Laboratory Medicine, University of Rochester Medical Center,
Rochester, NY 14642, USA
[16
]Department of Pathology and Laboratory Medicine, Hospital for Special Surgery, New
York, NY 10021, USA
[17
]Feinstein Institute for Medical Research, Northwell Health, Manhasset, New York, NY
11030, USA
[18
]Division of Rheumatology and Clinical Immunology, University of Pittsburgh School
of Medicine, Pittsburgh, PA 15261 USA
[19
]Department of Surgery, Brigham and Women’s Hospital and Harvard Medical School, MA
02115, USA
[20
]Centre for Experimental Medicine & Rheumatology, William Harvey Research Institute,
Queen Mary University of London, E1 4NS, UK
[21
]NIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation
Trust and University of Birmingham, Birmingham, B15 2WB, UK
[22
]University Hospitals Birmingham NHS Foundation Trust, Birmingham, B15 2TH, UK
[23
]Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO 80220,
USA
[24
]Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester,
NY 14642, USA
[25
]Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal
Research, The University of Manchester, Oxford Road, Manchester, M13 9PT, UK
[26
]A list of members and affiliations appears at the end of the paper
[27
]Translational Research Program, Benaroya Research Institute at Virginia Mason, Seattle,
WA 98101, USA
[28
]Department of Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation,
Oklahoma City, OK 73104, USA
[29
]Graduate Program in Immunology and Microbial Pathogenesis, Weill Cornell Graduate
School of Medical Sciences, New York, NY 10065, USA
[30
]David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York,
NY 10021, USA
[31
]Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo
Medical and Dental University, Tokyo 113-8519, Japan
[32
]The Rockefeller University, New York, NY 10065, USA
[33
]Division of Immunology and Rheumatology, Department of Medicine, Stanford University
School of Medicine, Palo Alto, CA 94305, USA
[34
]The Institute for Immunity, Transplantation, and Infection, Stanford University School
of Medicine, CA 94305, USA
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