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      Serum Levels of Thyrotropin Are Decreased by Oral Calcium in Healthy Subjects but Not in Patients with Primary Hyperparathyroidism


      Hormone Research in Paediatrics

      S. Karger AG

      Calcium, TSH, Primary hyperparathyroidism

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          It has been suggested that calcium changes the set point of the pituitary thyroid feedback. It is not known, however, if small and slow changes of calcium and/or parathyroid hormone (PTH) within the physiological range influence the serum levels of thyrotropin (TSH) and thyroid hormones in healthy subjects or patients with primary hyperparathyroidism (pHPT). Nine healthy subjects and nine patients with pHPT were therefore investigated with an oral calcium load test. The patients were investigated before and 4 days after operation. During the test, serum levels of ionized calcium increased and serum levels of intact PTH decreased in both healthy subjects and patients pre- and postoperatively (p < 0.001). Furthermore, in patients, the suppressibility of serum levels of PTH by calcium increased postoperatively (p < 0.05). Serum levels of TSH decreased during the oral calcium load in healthy subjects (p < 0.01) but not in patients, whereas the serum levels of thyroid hormones did not change. It is concluded that oral calcium influences TSH secretion in healthy humans but not in patients with pHPT.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          05 December 2008
          : 42
          : 6
          : 273-277
          Department of Surgery, Lund University, Lund, Sweden
          184208 Horm Res 1994;42:273–277
          © 1994 S. Karger AG, Basel

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          Pages: 5
          Original Paper


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