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      Influence of Body Iron Stores on the Serum Erythropoietin Concentration in Hemodialyzed Patients

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          Abstract

          The influence of body iron stores on the concentration of serum erythropoietin was studied in 48 hemodialyzed patients not receiving human recombinant erythropoietin, androgens or iron supplements. The serum erythropoietin concentration was 11.6 ± 10.4 mlU/ml. There was no correlation between the serum erythropoietin and the hematocrit or hemoglobin concentration; however, there was a correlation between the serum erythropoietin and the log of serum ferritin (r = -0.5699, p < 0.01). Serum erythropoietin levels were higher in the 18 ferropenic patients (serum ferritin < 50 ng/ml) than in the 30 patients with normal serum ferritin concentration (18 ± 13.8 vs. 7.8 ± 4.7 mlU/ml, p < O.01). The administration of intravenous iron to the ferropenic patients resulted in a reduction in serum erythropoietin independent of the respone of the anemia (18 ± 13.8 basal and 7.9 ± 6.5 mIU/mlat4weeks, p < 0.01). Our data would suggest that the concentration of erythropoietin in hemodialyzed patients is influenced by the serum ferritin level.

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          Author and article information

          Journal
          AJN
          Am J Nephrol
          10.1159/issn.0250-8095
          American Journal of Nephrology
          S. Karger AG
          0250-8095
          1421-9670
          1994
          1994
          28 October 2008
          : 14
          : 2
          : 95-98
          Affiliations
          Department of Nephrology, Hospital Ramón y Cajal, Madrid, Spain
          Article
          168696 Am J Nephrol 1994;14:95–98
          10.1159/000168696
          8080013
          87032a90-62d1-4303-8e48-3d92b28946b9
          © 1994 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          : 12 January 1993
          : 04 January 1994
          Page count
          Pages: 4
          Categories
          Clinical Study

          Cardiovascular Medicine,Nephrology
          Hemodialysis,Anemia,Erythropoietin,Iron stores
          Cardiovascular Medicine, Nephrology
          Hemodialysis, Anemia, Erythropoietin, Iron stores

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