7
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Retraction: MicroRNA-377 Suppresses Cell Proliferation and Invasion by Inhibiting TIAM1 Expression in Hepatocellular Carcinoma

      retraction
      The PLOS ONE Editors
      PLoS ONE
      Public Library of Science

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          After this article [1] was published, similarities were noted between this article and submissions by other research groups (including [2]) which call into question the validity and provenance of the reported results and the adherence of this article to the PLOS Authorship policy. It also came to light that there is extensive text overlap between this article [1] and previously published work. In light of these issues, the PLOS ONE Editors retract this article. The authors either could not be reached or did not respond to recent correspondence about this matter.

          Related collections

          Most cited references2

          • Record: found
          • Abstract: found
          • Article: found
          Is Open Access

          MicroRNA-377 Suppresses Cell Proliferation and Invasion by Inhibiting TIAM1 Expression in Hepatocellular Carcinoma

          Increasing evidence has suggested that microRNAs (miRNAs) play an important role in the initiation and progression of hepatocellular carcinoma (HCC). Here, we identified a novel tumor suppressive miRNA, miR-377, and investigated its role in HCC. The expression of miR-377 in HCC tissues and cell lines was detected by real-time reverse-transcription PCR. The effects of miR-377 on HCC cell proliferation and invasion were also investigated. Western blot and luciferase reporter assay were used to identify the direct and functional target of miR-377. The expression of miR-377 was markedly downregulated in human HCC tissues and cell lines. MiR-377 can dramatically inhibit cell growth and invasion in HCC cells. Subsequent investigation revealed that T lymphoma invasion and metastasis 1 (TIAM1) was a direct and functional target of miR-377 in HCC cells. Overexpression of miR-377 impaired TIAM1-induced promotion of proliferation and invasion in HCC cells. Finally, miR-377 is inversely correlated with TIAM1 expression in human HCC tissues. These findings reveal that miR-377 functions as a tumor suppressor and inhibits the proliferation and invasion of HCC cells by targeting TIAM1, which may consequently serve as a therapeutic target for HCC patients.
            Bookmark
            • Record: found
            • Abstract: found
            • Article: found
            Is Open Access

            MiR-506 Suppresses Tumor Proliferation and Invasion by Targeting FOXQ1 in Nasopharyngeal Carcinoma

            MiRNAs are small noncoding RNAs that play important roles in various biological processes including tumorigenesis. However, little is known about the expression and function of miR-506 in nasopharyngeal carcinoma (NPC). In this study, we showed that miR-506 was downregulated in nasopharyngeal carcinoma (NPC) cell lines and tissues. Ectopic expression of miR-506 dramatically suppressed cell proliferation, colony formation and invasion. Moreover, we identified the Forkhead box Q1 (FOXQ1) gene as a novel direct target of miR-506. MiR-506 exerts its tumor suppressor function through inhibition of the FOXQ1, which was involved in tumor metastasis and proliferation in various cancers. Furthermore, the expression of FOXQ1 is up-regulated in NPC cell lines and tissues. Taken together, our results indicate that miR-506 functions as a tumor suppressor miRNA in NPC and that its suppressive effects are mediated chiefly by repressing FOXQ1 expression.
              Bookmark

              Author and article information

              Journal
              PLoS One
              PLoS One
              plos
              PLoS ONE
              Public Library of Science (San Francisco, CA USA )
              1932-6203
              24 March 2022
              2022
              24 March 2022
              : 17
              : 3
              : e0266302
              Article
              PONE-D-22-08154
              10.1371/journal.pone.0266302
              8947015
              35325011
              87077a1b-86bf-4f43-aad5-2039ed0ff7e2
              © 2022 The PLOS ONE Editors

              This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

              History
              Page count
              Figures: 0, Tables: 0, Pages: 1
              Categories
              Retraction

              Uncategorized
              Uncategorized

              Comments

              Comment on this article