East asian variant of aldehyde dehydrogenase 2 is associated with coronary spastic angina: possible roles of reactive aldehydes and implications of alcohol flushing syndrome.

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Abstract

Coronary spastic angina (CSA) is a common disease among East Asians, including Japanese. The prevalence of alcohol flushing syndrome associated with deficient activity of the variant aldehyde dehydrogenase 2 (ALDH2*2) genotype is prevalent among East Asians. We examined whether CSA is associated with the ALDH2*2 genotype in Japanese.

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Journal ID (iso-abbrev): Circulation

Title: Circulation

Publisher: Ovid Technologies (Wolters Kluwer Health)

ISSN (Electronic): 1524-4539

ISSN (Print): 0009-7322

Publication date (Electronic): May 12 2015

Volume: 131

Issue: 19

Affiliations

[1 ] From Division of Cardiovascular Medicine, Kumamoto Kinoh Hospital, Kumamoto Aging Research Institute, Kumamoto, Japan (Y.M., E.H., S.M., M.S., H.Y.); Department of Cardiology, Nagoya University, Graduate School of Medicine, Nagoya, Japan (S.M., T.M.); School of Pharmaceutical Sciences, Mukogawa Women's University, Koshien, Nishinomiya, Japan (K.K., M.H.); Division of Cardiovascular Medicine, Nara City Hospital, Nara, Japan (Y.M.); Nakayama Cardiovascular Clinic, Amakusa, Japan (M.N.); and Division of Cardiology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan (M.Y.).

[2 ] From Division of Cardiovascular Medicine, Kumamoto Kinoh Hospital, Kumamoto Aging Research Institute, Kumamoto, Japan (Y.M., E.H., S.M., M.S., H.Y.); Department of Cardiology, Nagoya University, Graduate School of Medicine, Nagoya, Japan (S.M., T.M.); School of Pharmaceutical Sciences, Mukogawa Women's University, Koshien, Nishinomiya, Japan (K.K., M.H.); Division of Cardiovascular Medicine, Nara City Hospital, Nara, Japan (Y.M.); Nakayama Cardiovascular Clinic, Amakusa, Japan (M.N.); and Division of Cardiology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan (M.Y.). yasue@juryo.or.jp.

Article

Publisher Item ID: CIRCULATIONAHA.114.013120

DOI: 10.1161/CIRCULATIONAHA.114.013120

PubMed ID: 25759460

SO-VID: 87089827-e21d-45ea-8340-4e66a738cfbc

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Keywords: alcohol,aldehyde dehydrogenase,coronary spasm,coronary spastic angina

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Keywords: alcohol, aldehyde dehydrogenase, coronary spasm, coronary spastic angina

East asian variant of aldehyde dehydrogenase 2 is associated with coronary spastic angina: possible roles of reactive aldehydes and implications of alcohol flushing syndrome.

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