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Aquaretic effects of niravoline, a kappa-opioid agonist, in patients with cirrhosis.
Jan 2000
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Abstract
In patients with cirrhosis, decreased renal water excretion is a common complication. Niravoline (RU51599), a kappa-opioid receptor agonist, has been shown to induce an aquaretic response. The aim of this study was to evaluate the aquaretic effect and tolerance of niravoline in patients with cirrhosis.