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      Single-Fraction Versus Multifraction (3 × 9 Gy) Stereotactic Radiosurgery for Large (>2 cm) Brain Metastases: A Comparative Analysis of Local Control and Risk of Radiation-Induced Brain Necrosis.

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          Abstract

          To investigate the local control and radiation-induced brain necrosis in patients with brain metastases >2 cm in size who received single-fraction or multifraction stereotactic radiosurgery (SRS); factors associated with clinical outcomes and the development of brain radionecrosis were assessed.

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          Author and article information

          Journal
          Int. J. Radiat. Oncol. Biol. Phys.
          International journal of radiation oncology, biology, physics
          Elsevier BV
          1879-355X
          0360-3016
          Jul 15 2016
          : 95
          : 4
          Affiliations
          [1 ] Unit of Radiation Oncology, Sant'Andrea Hospital, Sapienza University of Rome, Rome, Italy; IRCCS Neuromed, Pozzilli, Italy. Electronic address: gminniti@ospedalesantandrea.it.
          [2 ] Unit of Radiation Oncology, Sant'Andrea Hospital, Sapienza University of Rome, Rome, Italy.
          [3 ] IRCCS Neuromed, Pozzilli, Italy.
          [4 ] Unit of Neuroradiology, Sant'Andrea Hospital, Sapienza University of Rome, Rome, Italy.
          [5 ] Unit of Nuclear Medicine, Sant'Andrea Hospital, Sapienza University of Rome, Rome, Italy.
          Article
          S0360-3016(16)00325-4
          10.1016/j.ijrobp.2016.03.013
          27209508
          870c7bea-941b-4919-a27f-2060bbace9ab
          History

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