Changes in rat lens proteins and glutathione reductase activity with advancing age

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Abstract

We examined the changes in the amounts of water-soluble and water-insoluble proteins of rat lenses, and in glutathione reductase activity and glutathione reductase gene expression, with advancing age. The lens total protein increased in 1-month-old rats, 3-month-old rats, and 6-month-old rats, but thereafter decreased in 12-month-old-rats. The water-soluble proteins decreased with advancing age, while the water-insoluble proteins increased. The glutathione reductase activity decreased with advancing age, but the decreased glutathione reductase activity almost recovered by addition of flavin adenine dinucleotide (FAD) in vitro. However, advancing age had no effect on the level of mRNA for glutathione reductase.

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Journal

Journal ID (publisher-id): vit

Journal ID (MPID): 122286

Title: International Journal for Vitamin and Nutrition Research

Publisher: Hogrefe AG, Bern

ISSN (Print): 0300-9831

ISSN (Electronic): 1664-2821

Publication date (Print): 1 September 2004

Publication date (Electronic): 14 March 2013

Volume: 74

Issue: 5 ( otherID: N7364Q7U4707 )

Pages: 329-333

Affiliations

[ ¹ ] Department of Biochemistry, School of Medicine, Iwate Medical University and Division of Basic Science, Iwate College of Nursing

[ ² ] Department of Biochemistry, School of Medicine, Iwate Medical University

[ ³ ] Department of Chemistry, School of Liberal Art and Sciences, Iwate Medical University

Article

Other ID: E2K43N440314436X

DOI: 10.1024/0300-9831.74.5.329

SO-VID: 870d4949-860e-4620-b37a-b03dc49a9384

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