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      Inward Remodeling Follows Chronic Vasoconstriction in Isolated Resistance Arteries

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          The hypothesis was tested that chronic vasoconstriction is followed by a structural reduction in lumen diameter, measured at full dilation. An in vitro model of pressurized rat skeletal muscle arterioles was used. During a 3-day experimental period, constriction of active vessels was achieved with fetal calf serum or endothelin-1 (ET-1). Maximal dilation revealed inward remodeling from 179 ± 6.5 µm lumen diameter on day 0 to 151 ± 6.3 µm on day 3 at 75 mm Hg in vessels incubated with serum (n = 8). Similarly, ET-1 induced inward remodeling from 182 ± 5.2 to 164 ± 3.7 µm (n = 6). When constriction during organoid culture was inhibited with papaverin or verapamil, inward remodeling was fully prevented: 184 ± 6.3 to 184 ± 5.8 µm for papaverin (n = 6) and 174 ± 5.5 to 177 ± 7.4 µm for verapamil (n = 6). A chronic reduction in diameter without tone was achieved in vessels that were kept at a low pressure (2–5 mm Hg; n = 6). Here, no remodeling was found, thereby ruling out that a chronic reduction in diameter alone is sufficient for inward remodeling. These data show that a persistent active reduction in lumen diameter is followed by inward remodeling of arterioles.

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          Vasoactive effects of growth factors


            Author and article information

            J Vasc Res
            Journal of Vascular Research
            S. Karger AG
            February 2002
            13 February 2002
            : 39
            : 1
            : 12-20
            Academic Medical Center, University of Amsterdam, aDepartment of Medical Physics and Cardiovascular Research Institute Amsterdam (CRIA), bDepartment of Cell Biology and Histology and Department of Periodontology, Academic Center for Dentistry, Amsterdam,The Netherlands
            48989 J Vasc Res 2002;39:12–20
            © 2002 S. Karger AG, Basel

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            Page count
            Figures: 6, References: 16, Pages: 9
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