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      Final Height in a Large Cohort of Dutch Patients with Growth Hormone Deficiency Treated with Growth Hormone

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          Final height was evaluated in 203 patients with growth hormone (GH) deficiency, who had been treated with GH in childhood, and was related to other factors. Mean final height was 168.1 cm (men) and 154.7 cm (women), -2.07 and -2.20 SD of the population mean, respectively. Patients with GH deficiency due to cerebral tumour were taller than those with idiopathic GH deficiency, and patients with induced puberty were taller than those with spontaneous puberty. Target height (r = +0.37), birth length (r = 0.36), height SDS at the start of therapy (r = +0.51) and at the start of puberty (r = +0.58) were significantly correlated with final height. Multiple linear regression analysis revealed that after correction for height at the start of puberty, age at the start of puberty was also positively correlated with final height. Patients who were treated after 1983 (when treatment regimens were changed) were taller than patients who finished treatment before 1983. The results suggest the importance of preventing a large initial height deficit and attaining optimal height at the start of puberty.

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          Author and article information

          Hormone Research in Paediatrics
          S. Karger AG
          05 December 2008
          : 43
          : 4
          : 135-137
          aDepartment of Paediatrics, University Hospital Leiden; bBureau of the Dutch Growth Foundation, Leiden, The Netherlands
          184259 Horm Res 1995;43:135–137
          © 1995 S. Karger AG, Basel

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          Page count
          Pages: 3
          Session I: Final Height in GHD Children


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