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      When age really matters; ferritin reference intervals during infancy revisited.

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          Abstract

          Infants are at risk for iron deficiency. Despite research advances, assessing iron stores during infancy remains a challenge to the clinician. Ferritin is the first-choice laboratory marker for measuring iron stores but it is today still unclear how to evaluate reference intervals among infants. We have studied Swedish infants (n = 456), born at term after normal pregnancies. Ferritin was measured at birth (umbilical cord sample), 48-72 h, 4 months and 12 months. Lower and upper reference interval limits were constructed as the 2.5th and 97.5th percentiles. By a large study population, we were able to use more stringent measures to avoid interference from the acute phase response than previous reports on ferritin reference intervals. When we used mathematical transformation we furthermore avoided potential information loss in precision and confirmed earlier reports of sex differences. At the lower reference interval limits there were small differences between sexes. For the higher limits, the differences were more pronounced in the older infant. At 0-3 d of age we observed a difference between the sexes of only 5% at the upper limits. The differences peaked at 12 months, where the boys' upper 97.5th percentile was 56% compared to girls.

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          Author and article information

          Journal
          Scand J Clin Lab Invest
          Scandinavian journal of clinical and laboratory investigation
          Informa UK Limited
          1502-7686
          0036-5513
          Dec 2019
          : 79
          : 8
          Affiliations
          [1 ] Department of Clinical Chemistry, Hospital of Halland, Varberg Sweden.
          [2 ] Department of Clinical Sciences Lund, Pediatrics/Neonatology, Lund University, Lund, Sweden.
          [3 ] Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
          [4 ] Department of Clinical Sciences, Pediatrics, Umeå University, Umeå, Sweden.
          Article
          10.1080/00365513.2019.1681028
          31642699
          872a3b74-7012-4358-ba2e-5b8fd474c031
          History

          Ferritin,infant,iron deficiency,pediatrics,reference intervals

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