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      Artificial Intelligence for COVID-19: Rapid Review

      research-article
      , MBBS 1 , , , MBBS, MRCP, MPH, MHPE, EDIC 1 , 2
      ,
      (Reviewer), (Reviewer)
      Journal of Medical Internet Research
      JMIR Publications
      coronavirus, deep learning, machine learning, medical informatics, computing, SARS virus, COVID-19, artificial intelligence, review

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          Abstract

          Background

          COVID-19 was first discovered in December 2019 and has since evolved into a pandemic.

          Objective

          To address this global health crisis, artificial intelligence (AI) has been deployed at various levels of the health care system. However, AI has both potential benefits and limitations. We therefore conducted a review of AI applications for COVID-19.

          Methods

          We performed an extensive search of the PubMed and EMBASE databases for COVID-19–related English-language studies published between December 1, 2019, and March 31, 2020. We supplemented the database search with reference list checks. A thematic analysis and narrative review of AI applications for COVID-19 was conducted.

          Results

          In total, 11 papers were included for review. AI was applied to COVID-19 in four areas: diagnosis, public health, clinical decision making, and therapeutics. We identified several limitations including insufficient data, omission of multimodal methods of AI-based assessment, delay in realization of benefits, poor internal/external validation, inability to be used by laypersons, inability to be used in resource-poor settings, presence of ethical pitfalls, and presence of legal barriers. AI could potentially be explored in four other areas: surveillance, combination with big data, operation of other core clinical services, and management of patients with COVID-19.

          Conclusions

          In view of the continuing increase in the number of cases, and given that multiple waves of infections may occur, there is a need for effective methods to help control the COVID-19 pandemic. Despite its shortcomings, AI holds the potential to greatly augment existing human efforts, which may otherwise be overwhelmed by high patient numbers.

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          Most cited references67

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          Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China

          In December 2019, novel coronavirus (2019-nCoV)-infected pneumonia (NCIP) occurred in Wuhan, China. The number of cases has increased rapidly but information on the clinical characteristics of affected patients is limited.
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            A pneumonia outbreak associated with a new coronavirus of probable bat origin

            Since the outbreak of severe acute respiratory syndrome (SARS) 18 years ago, a large number of SARS-related coronaviruses (SARSr-CoVs) have been discovered in their natural reservoir host, bats 1–4 . Previous studies have shown that some bat SARSr-CoVs have the potential to infect humans 5–7 . Here we report the identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China. The epidemic, which started on 12 December 2019, had caused 2,794 laboratory-confirmed infections including 80 deaths by 26 January 2020. Full-length genome sequences were obtained from five patients at an early stage of the outbreak. The sequences are almost identical and share 79.6% sequence identity to SARS-CoV. Furthermore, we show that 2019-nCoV is 96% identical at the whole-genome level to a bat coronavirus. Pairwise protein sequence analysis of seven conserved non-structural proteins domains show that this virus belongs to the species of SARSr-CoV. In addition, 2019-nCoV virus isolated from the bronchoalveolar lavage fluid of a critically ill patient could be neutralized by sera from several patients. Notably, we confirmed that 2019-nCoV uses the same cell entry receptor—angiotensin converting enzyme II (ACE2)—as SARS-CoV.
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              Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement

              David Moher and colleagues introduce PRISMA, an update of the QUOROM guidelines for reporting systematic reviews and meta-analyses
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                Author and article information

                Contributors
                Journal
                J Med Internet Res
                J Med Internet Res
                JMIR
                Journal of Medical Internet Research
                JMIR Publications (Toronto, Canada )
                1439-4456
                1438-8871
                October 2020
                27 October 2020
                27 October 2020
                : 22
                : 10
                : e21476
                Affiliations
                [1 ] Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore
                [2 ] Division of Respiratory & Critical Care Medicine Department of Medicine National University Hospital Singapore Singapore
                Author notes
                Corresponding Author: Jiayang Chen jiayang_chen1997@ 123456live.com
                Author information
                https://orcid.org/0000-0003-1900-0935
                https://orcid.org/0000-0003-2528-7282
                Article
                v22i10e21476
                10.2196/21476
                7595751
                32946413
                873067f2-8352-43a9-9fc8-a363a2ee4d1d
                ©Jiayang Chen, Kay Choong See. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 27.10.2020.

                This is an open-access article distributed under the terms of the Creative Commons Attribution License ( https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in the Journal of Medical Internet Research, is properly cited. The complete bibliographic information, a link to the original publication on http://www.jmir.org/, as well as this copyright and license information must be included.

                History
                : 16 June 2020
                : 13 July 2020
                : 25 July 2020
                : 15 September 2020
                Categories
                Review
                Review

                Medicine
                coronavirus,deep learning,machine learning,medical informatics,computing,sars virus,covid-19,artificial intelligence,review

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