0
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found

      Morphologic and Metabolic Characteristics of Ventral, Lateral, Dorsal and Anterior Prostate Transplants in Rats

      ,

      Hormone Research in Paediatrics

      S. Karger AG

      Rat prostate, Transplant, Testosterone, Prolactin

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Anterior, dorsal, lateral, and ventral prostate lobe transplants derived from 12-week-old donor F<sub>344</sub> rats were maintained in the cleared 5th mammary fat pads of 3-week-old testosterone propionate (TP)-implanted female and TP-implanted and unimplanted male syngeneic hosts for 12 posttransplantation weeks. Prostate transplants failed to survive in untreated female hosts. Implantation of TP pellets in male hosts resulted in an increase in the number of surviving transplants as well as in the ability of these transplants to biotransform testosterone-<sup>3</sup>H (T-<sup>3</sup>H) to its major radiometabolites (dihydrotestosterone-<sup>3</sup>H and androstanediol-<sup>3</sup>H) in vitro. TP implants + prolactin (50IU/kg daily i.p. injections for the 5 days prior to sacrifice) caused a marked increase in prostate weight and in epithelial secretory activity. Whereas the anterior, dorsal, and ventral lobe transplant showed acini with normal columnar epithelium and secretory activity, the epithelial cells in the lateral lobe transplants were often very irregular. In general, those prostate transplants which showed an ability to metabolize testosterone were also those exhibiting normal secretory epithelium.

          Related collections

          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          1663-2818
          1663-2826
          1980
          1980
          25 November 2008
          : 13
          : 1
          : 28-39
          Affiliations
          Department of Pharmacology and Toxicology, West Virginia University Medical Center, Morgantown, W.Va.
          Article
          179268 Horm Res 1980;13:28–39
          10.1159/000179268
          7439884
          © 1980 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 12
          Categories
          Original Paper

          Comments

          Comment on this article