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      PTH [1-34]-induced alterations of the subchondral bone provoke early osteoarthritis.

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          Abstract

          To test the hypothesis that changes in the subchondral bone induced by parathyroid hormone (PTH [1-34]) reciprocally affect the integrity of the articular cartilage within a naïve osteochondral unit in vivo.

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          Author and article information

          Journal
          Journal ID (iso-abbrev): Osteoarthr. Cartil.
          Title: Osteoarthritis and cartilage
          Publisher: Elsevier BV
          ISSN (Electronic): 1522-9653
          ISSN (Print): 1063-4584
          Publication date (Electronic): Jun 2014
          Volume: 22
          Issue: 6
          Affiliations
          [1 ] Center of Experimental Orthopaedics, Saarland University, Homburg/Saar, Germany; Department of Orthopaedic Surgery, Saarland University Medical Center, Homburg/Saar, Germany. Electronic address: patrick.orth@uks.eu.
          [2 ] Center of Experimental Orthopaedics, Saarland University, Homburg/Saar, Germany. Electronic address: mmcucchiarini@hotmail.com.
          [3 ] Institute of Medical Biometry, Epidemiology and Medical Informatics, Saarland University Medical Center, Homburg/Saar, Germany. Electronic address: imbei@med-imbei.uni-saarland.de.
          [4 ] Institute for Clinical and Experimental Surgery, Saarland University Medical Center, Saarland University, Homburg/Saar, Germany. Electronic address: michael.menger@uks.eu.
          [5 ] Center of Experimental Orthopaedics, Saarland University, Homburg/Saar, Germany; Department of Orthopaedic Surgery, Saarland University Medical Center, Homburg/Saar, Germany. Electronic address: henning.madry@uks.eu.
          Article
          Publisher Item ID: S1063-4584(14)01011-5
          DOI: 10.1016/j.joca.2014.03.010
          PubMed ID: 24662735
          SO-VID: 87501ea6-9a97-4a23-b892-1c890aef0aac
          History

          Keywords: Articular cartilage,Early osteoarthritis,Femoral head,Osteochondral unit,PTH [1-34],Subchondral bone
          Data availability:
          Keywords: Articular cartilage, Early osteoarthritis, Femoral head, Osteochondral unit, PTH [1-34], Subchondral bone

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