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      The levels of glutathione and nitrite-nitrate and the expression of Bcl-2 mRNA in ovariectomized rats treated by raloxifene against kainic acid.

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          Abstract

          The selective estrogen receptor modulators (SERMs) are compounds that activate the estrogen receptors with different estrogenic and antiestrogenic tissue-specific effects. The similar effects of SERMs on estrogen encourage the efforts in the research of neuroprotective effects of SERMs. In our study, the potential neuroprotective effects of raloxifene were investigated on the brain cortex of ovariectomized rats after kainic acid-induced oxidative stress. To show the neuroprotective effect of raloxifene against a neurodegenerative agent, kainic acid, expression of Bcl-2, total glutathione (GSH), and nitrite-nitrate levels were investigated in the rat brain cortex. Our results demostrate that raloxifene treatment against oxidative stress significantly increases the expression of Bcl-2 and the level of GSH in the brain cortex.

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          Author and article information

          Journal
          Int. J. Neurosci.
          The International journal of neuroscience
          1563-5279
          0020-7454
          2009
          : 119
          : 2
          Affiliations
          [1 ] Department of Biochemistry, Faculty of Pharmacy, Ege University, Bornova, Izmir, Turkey. guliz.durmaz@ege.edu.tr
          Article
          907383890
          10.1080/00207450802330959
          19125376
          875476e9-f7da-4113-bb23-db3df3001786
          History

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