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      An updated review of Terminalia catappa

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          Abstract

          Terminalia catappa Linn. is known for its nutritional fruit and possesses medicinal benefits as well. This is a comprehensive review of the phytoconstituents and pharmacological benefits. T. catappa has been recognized for its medicinally essential phytoconstituents, such as phenol, flavonoid, and carotenoid. Numerous pharmacological investigations have confirmed this plant's ability to exhibit antimicrobial, anti-inflammatory, antidiabetic, antioxidant, hepatoprotective, and anticancer activities, all of which support its traditional uses.

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          Most cited references 55

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          Oncogenes and cancer.

           Carlo Croce (2008)
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            Antioxidant and hepatoprotective actions of medicinal herb, Terminalia catappa L. from Okinawa Island and its tannin corilagin.

             S Nakama,  Y Aniya,  T Ichiba (2007)
            The antioxidant and hepatoprotective actions of Terminalia catappa L. collected from Okinawa Island were evaluated in vitro and in vivo using leaves extract and isolated antioxidants. A water extract of the leaves of T. catappa showed a strong radical scavenging action for 1,1-diphenyl-2-picrylhydrazyl and superoxide (O(2)(.-)) anion. Chebulagic acid and corilagin were isolated as the active components from T. catappa. Both antioxidants showed a strong scavenging action for O(2)(.-) and peroxyl radicals and also inhibited reactive oxygen species production from leukocytes stimulated by phorbol-12-myristate acetate. Galactosamine (GalN, 600 mg/kg, s.c.,) and lipopolysaccharide (LPS, 0.5 microg/kg, i.p.)-induced hepatotoxicity of rats as seen by an elevation of serum alanine aminotransferase, aspartate aminotransferase and glutathione S-transferase (GST) activities was significantly reduced when the herb extract or corilagin was given intraperitoneally to rats prior to GalN/LPS treatment. Increase of free radical formation and lipid peroxidation in mitochondria caused by GalN/LPS treatment were also decreased by pretreatment with the herb/corilagin. In addition, apoptotic events such as DNA fragmentation and the increase in caspase-3 activity in the liver observed with GalN/LPS treatment were prevented by the pretreatment with the herb/corilagin. These results show that the extract of T. catappa and its antioxidant, corilagin are protective against GalN/LPS-induced liver injury through suppression of oxidative stress and apoptosis.
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              Antidiabetic activity of Terminalia catappa Linn fruits.

              In view of alleged antidiabetic potential, effect of the petroleum ether, methanol, and aqueous extracts of Terminalia catappa Linn (combretaceae) fruit, on fasting blood sugar levels and serum biochemical analysis in alloxan-induced diabetic rats were investigated. All the three extracts of Terminalia catappa produced a significant antidiabetic activity at dose levels 1/5 of their lethal doses. Concurrent histological studies of the pancreas of these animals showed comparable regeneration by methanolic and aqueous extracts which were earlier, necrosed by alloxan.
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                Author and article information

                Affiliations
                Department of Science and Humanities, MIET Engineering College, Tiruchirappalli, India
                [1 ] Department of Biochemistry, MIET Engineering College, Tiruchirappalli, India
                [2 ] Department of Biochemistry, Kanchi Shri Krishna College of Arts and Science, Kancheepuram, Tamil Nadu, India
                Author notes
                Address for correspondence: Dr. A. Vijaya Anand, Department of Science and Humanties, MIET Engineering College, Gundur, Tiruchirappalli - 620 007, Tamil Nadu, India. E-mail: avamiet@ 123456yahoo.com
                Journal
                Pharmacogn Rev
                Pharmacogn Rev
                PRev
                Pharmacognosy Reviews
                Medknow Publications & Media Pvt Ltd (India )
                0973-7847
                0976-2787
                Jul-Dec 2015
                : 9
                : 18
                : 93-98
                PRev-9-93
                10.4103/0973-7847.162103
                4557241
                Copyright: © Pharmacognosy Reviews

                This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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