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Efficacy, safety and immunogenicity of heptavalent pneumococcal conjugate vaccine in children. Northern California Kaiser Permanente Vaccine Study Center Group.
S Black
1 ,
H Shinefield ,
B Fireman ,
E Lewis ,
P Ray ,
J R Hansen ,
L Elvin ,
K M Ensor ,
J Hackell ,
G Siber ,
F Malinoski ,
D Madore ,
I Chang ,
R Kohberger ,
W Watson ,
R Austrian ,
K Edwards
Mar 2000
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Abstract
To determine the efficacy, safety and immunogenicity of the heptavalent CRM197 pneumococcal conjugate vaccine against invasive disease caused by vaccine serotypes and to determine the effectiveness of this vaccine against clinical episodes of otitis media.