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      Catecholamine excretion profiles identify clinical subgroups of neuroblastoma patients.

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          Abstract

          Analysis of urinary catecholamine metabolites is one of the primary modalities to diagnose patients with neuroblastoma. Although catecholamine excretion patterns have been recognised in the past, their biological rationale and clinical relevance remain largely unknown. Therefore, this study was designed to identify unique catecholamine excretion patterns and elucidate their underlying biology and clinical relevance.

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          Author and article information

          Journal
          Eur J Cancer
          European journal of cancer (Oxford, England : 1990)
          Elsevier BV
          1879-0852
          0959-8049
          April 2019
          : 111
          Affiliations
          [1 ] Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands; Amsterdam UMC, University of Amsterdam, Department of Clinical Chemistry, Amsterdam Gastroenterology & Metabolism, Meibergdreef 9, Amsterdam, the Netherlands; Amsterdam UMC, University of Amsterdam, Department of Pediatric Oncology/Hematology, Emma Children's Hospital, Meibergdreef 9, Amsterdam, the Netherlands.
          [2 ] Amsterdam UMC, University of Amsterdam, Department of Clinical Chemistry, Amsterdam Gastroenterology & Metabolism, Meibergdreef 9, Amsterdam, the Netherlands.
          [3 ] Amsterdam UMC, University of Amsterdam, Department of Pathology, Meibergdreef 9, Amsterdam, the Netherlands.
          [4 ] Amsterdam UMC, University of Amsterdam, Department of Oncogenomics, Meibergdreef 9, Amsterdam, the Netherlands.
          [5 ] Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands; Amsterdam UMC, University of Amsterdam, Department of Pediatric Oncology/Hematology, Emma Children's Hospital, Meibergdreef 9, Amsterdam, the Netherlands. Electronic address: G.A.M.Tytgat@prinsesmaximacentrum.nl.
          Article
          S0959-8049(19)30035-8
          10.1016/j.ejca.2019.01.014
          30798085
          877e1d9f-ded2-4381-9a53-95f9f7ff0aee
          Copyright © 2019 Elsevier Ltd. All rights reserved.

          Neuroblastoma cell lines,Catecholamine biosynthetic enzymes,Catecholamine profiles,Clinical outcome,Clinical subgroups,Neuroblastoma patients

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