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      Evaluation of the ROS Inhibiting Activity and Mitochondrial Targeting of Phenolic Compounds in Fibroblast Cells Model System and Enhancement of Efficiency by Natural Deep Eutectic Solvent (NADES) Formulation.

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          Abstract

          Many phenolics have already been tested for their antioxidant activities using in vitro methods. However, such assays do not consider the complexity of real cellular systems, and most of the phenolics characterized with such assays shows disappointing results when evaluated in cells. Accordingly, there is a need to develop effective screening methods.

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          Author and article information

          Journal
          Pharm. Res.
          Pharmaceutical research
          Springer Nature
          1573-904X
          0724-8741
          May 2017
          : 34
          : 5
          Affiliations
          [1 ] CIRAD, UMR Ingénierie des Agropolymères et Technologies Émergentes, 2 place Viala, F-34060, Montpellier, France.
          [2 ] GSK Consumer Healthcare, Skin Health R&D, RTP, NC, USA.
          [3 ] INRA, UMR DMEM, F-34060, Montpellier, France.
          [4 ] GSK Consumer Healthcare Skin Health, GSK House, Brentford, UK.
          [5 ] CIRAD, UMR Ingénierie des Agropolymères et Technologies Émergentes, 2 place Viala, F-34060, Montpellier, France. villeneuve@cirad.fr.
          Article
          10.1007/s11095-017-2124-4
          10.1007/s11095-017-2124-4
          28224387
          87c97958-5d96-41fa-aacf-ba3e9fb79233
          History

          antioxidants,mitochondrial targeting,natural deep eutectic solvents,reactive oxygen species

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