14
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Nitrite as a vascular endocrine nitric oxide reservoir that contributes to hypoxic signaling, cytoprotection, and vasodilation.

      American Journal of Physiology - Heart and Circulatory Physiology
      Animals, Cell Hypoxia, Cytoprotection, Endocrine System, enzymology, metabolism, physiology, Hemoglobins, Humans, Models, Biological, Nitric Oxide, Nitrites, pharmacology, Vasodilation

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Accumulating evidence suggests that the simple and ubiquitous anion salt, nitrite (NO(2)(-)), is a physiological signaling molecule with potential roles in intravascular endocrine nitric oxide (NO) transport, hypoxic vasodilation, signaling, and cytoprotection after ischemia-reperfusion. Human and animal studies of nitrite treatment and NO gas inhalation provide evidence that nitrite mediates many of the systemic therapeutic effects of NO gas inhalation, including peripheral vasodilation and prevention of ischemia-reperfusion-mediated tissue infarction. With regard to nitrite-dependent hypoxic signaling, biochemical and physiological studies suggest that hemoglobin possesses an allosterically regulated nitrite reductase activity that reduces nitrite to NO along the physiological oxygen gradient, potentially contributing to hypoxic vasodilation. An expanded consideration of nitrite as a hypoxia-dependent intrinsic signaling molecule has opened up a new field of research and therapeutic opportunities for diseases associated with regional hypoxia and vasoconstriction.

          Related collections

          Author and article information

          Journal
          16798825
          10.1152/ajpheart.00407.2006

          Chemistry
          Animals,Cell Hypoxia,Cytoprotection,Endocrine System,enzymology,metabolism,physiology,Hemoglobins,Humans,Models, Biological,Nitric Oxide,Nitrites,pharmacology,Vasodilation

          Comments

          Comment on this article