Genes have been in the scientific vocabulary for a hundred years. The term "gene"
was proposed by the Danish plant scientist Wilhelm Johannsen in the first decade of
the 20th century. For Johannsen, the gene remained an abstract concept, "free of any
hypothesis" [1], but others were already pointing to chromosomes as the likely location
of genes. The science of genetics was born at that time, and genes were rapidly connected
with mutations, with patterns of inheritance, with development, with quantitative
traits, with evolution and with biochemical pathways. All this was achieved without
knowledge of the physical nature of genes, but this changed in mid-century with the
discoveries of molecular biology. DNA was revealed as the genetic material, and the
mechanisms were elucidated by which the information was encoded, and propagated, and
linked to the phenotype. However, the concept of a "gene" did not become clearer.
Quite the reverse, as the units of mutation, of recombination, of inheritance, of
expression, of regulation, etc. did not necessarily coincide.
Genes are so embedded in our intellectual DNA (to repatriate a fashionable idiom)
that we tend to forget that we still have no agreed definition of the term [2]. When
we say that there are fewer than 25,000 genes in the human genome [3], we are thinking
of protein-coding sequences, but are the associated introns and regulatory sequences
part of the gene? And what about splice variants, untranslated RNAs, epigenetic modifications?
These are important aspects of the genetic material and currently hot research topics.
Furthermore, genes still occupy a central place in our modern understanding of biology,
and all the connections that preoccupied our predecessors a century ago are still
lively issues. The explosion of genome data and of new techniques is generating new
insights in human diversity, developmental biology, molecular evolution, systems biology
and many other directions.
We may not know exactly what "genes" are, but I can tell you what Genes is. Genes
is a new Open Access, online-only journal covering all gene-related biology: genes,
genetics and genomics, and the science that they enable.
A list of some relevant keywords will give you a flavour of the scope: DNA; RNA; chromosomes;
reproduction; heredity; genealogy; interaction of multiple genes; genetic code; pseudogene;
gene structure; gene expression; recombination and linkage; genetic mapping; inheritance;
nature versus nurture; gene regulation; genetic change; population genetics; conservation
genetics; phylogenomics; phylogenetics; cloning; genetically modified organisms; human
genetics; comparative genomics; behavioural genetics; medical genetics; gene therapy;
genome projects; personal genomics; copy number variation; public health genomics;
genetic diversity; transcriptional profiling; microRNA analysis; mRNA analysis; analysis
of noncoding and other RNAs.
Why do we need a new journal in the area of genetics and genomics? It is true that
there are many established journals that cover this field, but the field itself is
expanding. The result is that good quality journals are receiving increasing numbers
of submissions, resulting in slow processing times for reviewing and publication and
a lottery in which perfectly sound papers can eventually be rejected. When you need
the publication for your final report, degree, promotion or next grant application,
such uncertainty can be stressful. Our aim for Genes is to reduce delays to a minimum
and to provide a good experience for authors and readers alike. That is why Genes
is an Open Access, online-only journal managed by a professional office in Switzerland.
The advantage of Open Access is that everyone with internet access can read the articles
at no cost – not just those at institutions that can afford the subscription. This
increases the number of people who read and cite the work. Of course, nothing is free
in this life, so the cost of publication is borne by the authors. The publication
charges of MDPI journals are relatively modest, though, compared to many other Open
Access journals, and certainly compared to the costs of carrying out the research.
Even better, publication charges will be waived for all articles that are submitted
to Genes before the end of 2010, so there is every incentive to submit your papers
soon.
The first advantage of an online-only journal is speed of publication. Genes is a
peer-reviewed publication: all manuscripts are evaluated by independent anonymous
referees in the usual way, but we will ensure that this is done as speedily as possible.
Once a manuscript is accepted, it can be prepared for on-line publication much faster
than for a print journal. Furthermore, there is no need to wait until an "issue" is
complete, so each article will be published as soon as it is ready. The result is
that work gets published faster and cited sooner. A further advantage of online publication
is that there is effectively no space limitation. There is no need to reject good
papers because the journal is "full", and every reason to make available all the relevant
data to support a study's findings.
I am happy to be supported in this venture by a strong Editorial Board of active scientists
who cover the wide remit of the journal. It is their expertise and judgment that will
ensure that the articles published in Genes will command respect and be worthy of
attention. Though we aim to be rapid, the peer review standards will be as high as
we have come to expect in this field. This journal is run by geneticists for geneticists.
We are fortunate to have the backing of MDPI, an organisation with more than a decade
of experience in online, Open Access science publishing, and dedicated editorial office
staff who have a science background.
Genes publishes reviews, research articles, communications and technical notes. In
addition, manuscripts regarding research proposals and research ideas will be particularly
welcomed. Special Issues are organised around a defined theme; they will often be
edited by a member of the Editorial Board, but we welcome proposals from the whole
genetics community. For example, a Special Issue may be devoted to selected papers
presented at a relevant conference. Articles do not have to be in a Special Issue,
however: independent submissions are welcome at any time, and accepted papers will
be published as soon as they are ready.
We aim to provide a rapid and hassle-free publication route for authors, so that they
will continue to come back to Genes with good manuscripts. If you have work to publish,
why not try us? It is free until the end of 2010.