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      Percutaneous closure of patent foramen ovale in patients with cryptogenic embolism: a network meta-analysis.

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          Abstract

          Up to 40% of ischaemic strokes are cryptogenic. A strong association between cryptogenic stroke and the prevalence of patent foramen ovale (PFO) suggests paradoxical embolism via PFO as a potential cause. Randomized trials failed to demonstrate superiority of PFO closure over medical therapy.

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          Author and article information

          Journal
          Eur. Heart J.
          European heart journal
          1522-9645
          0195-668X
          Jan 7 2015
          : 36
          : 2
          Affiliations
          [1 ] Department of Cardiology, Bern University Hospital, Bern, Switzerland.
          [2 ] Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland Department of Clinical Research, Clinical Trials Unit, Bern, Switzerland.
          [3 ] Department of Neurology, Bern University Hospital, Bern, Switzerland.
          [4 ] Department of Medicine/Cardiology, University of Colorado Denver, Aurora, CO, USA.
          [5 ] Cardiovascular Centre Frankfurt, Frankfurt am Main, Frankfurt, Germany.
          [6 ] Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland Department of Clinical Research, Clinical Trials Unit, Bern, Switzerland juni@ispm.unibe.ch.
          Article
          ehu292
          10.1093/eurheartj/ehu292
          25112661
          87e9d2f4-68f1-42c3-868b-9f6356be8029
          Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2014. For permissions please email: journals.permissions@oup.com.
          History

          Cryptogenic,Embolism,PFO,Patent foramen ovale,Stroke,Transcatheter closure

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