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      The Influence of Bradycardia and Normofrequent Ventricular Pacing on Myocardial Blood Flow and Energy Demand in Rats

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          Abstract

          The purpose of the present study was to determine the effect of β-blockade-induced bradycardia and normofrequent ventricular pacing (VP) on regional myocardial (MBF) and cerebral blood flow (CBF) as well as on myocardial oxygen consumption (MVO<sub>2</sub>) using colored microspheres. The MBF at sinus rhythm (SR) was 4.60 ± 1.27 ml/g/min and decreased to 3.80 ± 0.74 ml/g/min (p < 0.05) during β-blockade. The MBF was 5.10 ± 1.88 ml/g/min during VP with β-blockade. The endo-/epicardial MBF ratio during VP was significantly reduced. MVO<sub>2</sub> at β-blockade was significantly lower (0.21 ± 0.06 ml/g × min<sup>–1</sup>, p < 0.05) than at SR (0.47 ± 0.15 ml/g × min<sup>–1</sup>) and during VP with β-blockade (0.54 ± 0.14 ml/g × min<sup>–1</sup>). Results: (i) MBF and MVO<sub>2</sub> are reduced with decreasing mean arterial pressure (MAP) during β-blockade-induced bradycardia, but MBF and MVO<sub>2</sub> are significantly increased during normofrequent VP with β-blockade despite a further reduction in MAP. (ii) The MBF ratio is constant during β-blockade but is significantly lower during normofrequent VP with β-blockade. (iii) CBF remained constant during all experimental conditions. Conclusion: Despite β-blockade, the subendocardium is jeopardized during normofrequent VP by ischemia.

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          Most cited references 2

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          Association Between Hemodynamic Parameters and the Degeneration of Sustained Ventricular Tachycardias into Ventricular Fibrillation in Rats

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            Comparative effects of cardioselective versus noncardioselective beta blockade on subendocardial blood flow and contractile function in ischemic myocardium

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              Author and article information

              Journal
              CRD
              Cardiology
              10.1159/issn.0008-6312
              Cardiology
              S. Karger AG
              0008-6312
              1421-9751
              2003
              October 2003
              17 October 2003
              : 100
              : 2
              : 67-72
              Affiliations
              aAbteilung Kardiologie, Kerckhoff-Klinik, Bad Nauheim, and bAbteilung Kardiologie/Angiologie, Medizinische Klinik und Poliklinik, Universität Leipzig, Leipzig, Germany
              Article
              73041 Cardiology 2003;100:67–72
              10.1159/000073041
              14557692
              © 2003 S. Karger AG, Basel

              Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

              Page count
              Figures: 1, Tables: 2, References: 20, Pages: 6
              Categories
              General Cardiology – Basic Science

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