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      The Influence of Bradycardia and Normofrequent Ventricular Pacing on Myocardial Blood Flow and Energy Demand in Rats


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          The purpose of the present study was to determine the effect of β-blockade-induced bradycardia and normofrequent ventricular pacing (VP) on regional myocardial (MBF) and cerebral blood flow (CBF) as well as on myocardial oxygen consumption (MVO<sub>2</sub>) using colored microspheres. The MBF at sinus rhythm (SR) was 4.60 ± 1.27 ml/g/min and decreased to 3.80 ± 0.74 ml/g/min (p < 0.05) during β-blockade. The MBF was 5.10 ± 1.88 ml/g/min during VP with β-blockade. The endo-/epicardial MBF ratio during VP was significantly reduced. MVO<sub>2</sub> at β-blockade was significantly lower (0.21 ± 0.06 ml/g × min<sup>–1</sup>, p < 0.05) than at SR (0.47 ± 0.15 ml/g × min<sup>–1</sup>) and during VP with β-blockade (0.54 ± 0.14 ml/g × min<sup>–1</sup>). Results: (i) MBF and MVO<sub>2</sub> are reduced with decreasing mean arterial pressure (MAP) during β-blockade-induced bradycardia, but MBF and MVO<sub>2</sub> are significantly increased during normofrequent VP with β-blockade despite a further reduction in MAP. (ii) The MBF ratio is constant during β-blockade but is significantly lower during normofrequent VP with β-blockade. (iii) CBF remained constant during all experimental conditions. Conclusion: Despite β-blockade, the subendocardium is jeopardized during normofrequent VP by ischemia.

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          Association Between Hemodynamic Parameters and the Degeneration of Sustained Ventricular Tachycardias into Ventricular Fibrillation in Rats

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            Comparative effects of cardioselective versus noncardioselective beta blockade on subendocardial blood flow and contractile function in ischemic myocardium


              Author and article information

              S. Karger AG
              October 2003
              17 October 2003
              : 100
              : 2
              : 67-72
              aAbteilung Kardiologie, Kerckhoff-Klinik, Bad Nauheim, and bAbteilung Kardiologie/Angiologie, Medizinische Klinik und Poliklinik, Universität Leipzig, Leipzig, Germany
              73041 Cardiology 2003;100:67–72
              © 2003 S. Karger AG, Basel

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              Page count
              Figures: 1, Tables: 2, References: 20, Pages: 6
              General Cardiology – Basic Science


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