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      Glucose Variability in a 26-Week Randomized Comparison of Mealtime Treatment With Rapid-Acting Insulin Versus GLP-1 Agonist in Participants With Type 2 Diabetes at High Cardiovascular Risk.

      FLAT-SUGAR Trial Investigators
      Diabetes care
      American Diabetes Association

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          Abstract

          A1C is associated with diabetes complications but does not reflect glycemic variability (GV), which may worsen outcomes by inducing inflammation, oxidative stress, and cardiac arrhythmias. We tested whether a glucagon-like peptide 1 agonist-based regimen can reduce GV and cardiometabolic risk markers while maintaining similar A1C levels in people with insulin-requiring type 2 diabetes and high cardiovascular risk.

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          Author and article information

          Journal
          Diabetes Care
          Diabetes care
          American Diabetes Association
          1935-5548
          0149-5992
          June 2016
          : 39
          : 6
          Article
          dc15-2782
          10.2337/dc15-2782
          27208320
          8810ad60-6c03-4263-9bdf-4c7fef1b0df0
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