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      Genotyping errors: causes, consequences and solutions.

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          Abstract

          Although genotyping errors affect most data and can markedly influence the biological conclusions of a study, they are too often neglected. Errors have various causes, but their occurrence and effect can be limited by considering these causes in the production and analysis of the data. Procedures that have been developed for dealing with errors in linkage studies, forensic analyses and non-invasive genotyping should be applied more broadly to any genetic study. We propose a protocol for estimating error rates and recommend that these measures be systemically reported to attest the reliability of published genotyping studies.

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          Author and article information

          Journal
          Nat Rev Genet
          Nature reviews. Genetics
          Springer Science and Business Media LLC
          1471-0056
          1471-0056
          Nov 2005
          : 6
          : 11
          Affiliations
          [1 ] Laboratoire d'Ecologie Alpine, UMR CNRS 5553, Université Joseph Fourier, B.P. 53, 38041 Grenoble Cedex 9, France. francois.pompanon@ujf-grenoble.fr
          Article
          nrg1707
          10.1038/nrg1707
          16304600
          881887bf-5410-4853-b5c8-de1eeef50e18
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