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      Hemagglutination by Murine Hepatitis Viruses

      research-article
      Author(s): *
      Publication date (Electronic):
      Journal: Intervirology
      Publisher: S. Karger AG
      Keywords: Murine hepatitis virus, Coronavirus, Hemagglutination, Hemagglutinating activity

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          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Erythrocytes from twelve mammalian and avian sources in ten different buffers at three incubation temperatures could not be hemagglutinated with murine hepatitis virus (MHV) strains 3, A59, or S grown on DBT cells. Viral antigen preparation in the absence of fetal calf serum, partial virus purification, or various concentrations of red blood cells still failed to yield detectable hemagglutinating activity. Thus, the newly described MHV-DVIM remains the only hemagglutinating strain of murine coronavirus.

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          Techniques for hemagglutination and hemagglutination-inhibition with arthropod-borne viruses.

          D H CLARKE, J Casals (1958)
          Article 0 comments Cited 195 times – based on 0 reviews     Review now
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            The Molecular Biology of Coronaviruses

            Lawrence Sturman, Kathryn V. Holmes (1983)
            Publisher Summary Coronaviruses have recently emerged as an important group of animal and human pathogens that share a distinctive replicative cycle. Some of the unique characteristics in the replication of coronaviruses include generation of a 3' coterminal-nested set of five or six subgenomic mRNAs, each of which appears to direct the synthesis of one protein. Two virus-specific RNA polymerase activities have been identified. Many of the distinctive features of coronavirus infection and coronavirus-induced diseases may result from the properties of the two coronavirus glycoproteins. The intracellular budding site, which may be important in the establishment and maintenance of persistent infections, appears to be due to the restricted intracytoplasmic migration of the E1 glycoprotein, which acts as a matrix-like transmembrane glycoprotein. E1 also exhibits distinctive behavior by self-aggregating on heating at 100°C in sodium dodecyl sulfate (SDS) and by its interaction with RNA in the viral nucleocapsid. The E1 of mouse hepatitis virus (MHV) is an O-linked glycoprotein, unlike most other viral glycoproteins. Thus, the coronavirus system may be a useful model for the study of synthesis, glycosylation, and transport of O-linked cellular glycoproteins.
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              Coronavirus IBV: virus retaining spike glycopolypeptide S2 but not S1 is unable to induce virus-neutralizing or haemagglutination-inhibiting antibody, or induce chicken tracheal protection.

              R. Peters, J. Davis, D Cavanagh … (1986)
              Avian infectious bronchitis coronavirus (IBV) inactivated by beta-propiolactone induced partial protection of the trachea in up to 40% of chickens following one intramuscular inoculation 4 to 6 weeks prior to challenge. Retention of an intact tracheal ciliated epithelium 4 days after challenge was the criterion of protection. There was no correlation between protection and serum titres of virus-neutralizing (VN) and haemagglutination-inhibiting (HI) antibody, which were maximal at about 4 weeks after inoculation. Virus from which the S1 but not the S2 (spike-anchoring) spike glycopolypeptide had been removed by urea did not induce protection or VN or HI antibody. Four intramuscular inoculations of monomeric S1 induced VN and HI antibody in two and four chickens respectively. These results indicate that VN and HI antibodies are induced primarily by S1, that intact spikes are a major requirement for the induction of protective immunity and that this property is probably associated with S1.
              Article 0 comments Cited 96 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): Intervirology
                Journal ID (iso-abbrev): Intervirology
                Journal ID (publisher-id): INT
                Title: Intervirology
                Publisher: S. Karger AG (Allschwilerstrasse 10, P.O. Box · Postfach · Case postale, CH–4009, Basel, Switzerland · Schweiz · Suisse, Phone: +41 61 306 11 11, Fax: +41 61 306 12 34, karger@karger.com )
                ISSN (Print): 0300-5526
                ISSN (Electronic): 1423-0100
                Publication date (Print): July 1989
                Publication date (Electronic): 29 July 2008
                Volume: 30
                Issue: 2
                Pages: 117-120
                Affiliations
                Virology Research Center, Institut Armand-Frappier, Université du Quebec, Laval, Quebec, Canada
                Author notes
                *Dr. Pierre J. Talbot, Virology Research Center, Institut Armand-Frappier, Université du Québec, 531, bd des Prairies, Laval, Québec (Canada), H7N 4Z3
                Article
                Publisher ID: int-0030-0117
                DOI: 10.1159/000150083
                PMC ID: 7182640
                PubMed ID: 2542182
                SO-VID: 881f4da2-b0c5-4347-9046-fbf73c93701d
                Copyright © Copyright © 1989 by S. Karger AG, Basel
                License:

                This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.

                History
                Date received : 8 September 1988
                Date accepted : 15 November 1988
                Date: 1989
                Page count
                Tables: 1, References: 18, Pages: 4
                Categories
                Subject: Short Communication

                Keywords: murine hepatitis virus,coronavirus,hemagglutination,hemagglutinating activity
                Data availability:
                Keywords: murine hepatitis virus, coronavirus, hemagglutination, hemagglutinating activity

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