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Efficacy and effectiveness of an rVSV-vectored vaccine expressing Ebola surface glycoprotein: interim results from the Guinea ring vaccination cluster-randomised trial
Ana Maria Henao-Restrepo ,
Ira M Longini ,
Matthias Egger ,
Natalie E Dean ,
W John Edmunds ,
Anton Camacho ,
Miles W Carroll ,
Moussa Doumbia ,
Bertrand Draguez ,
Sophie Duraffour ,
Godwin Enwere ,
Rebecca Grais ,
Stephan Gunther ,
Stefanie Hossmann ,
Mandy Kader Kondé ,
Souleymane Kone ,
Eeva Kuisma ,
Myron M Levine ,
Sema Mandal ,
Gunnstein Norheim ,
Ximena Riveros ,
Aboubacar Soumah ,
Sven Trelle ,
Andrea S Vicari ,
Conall H Watson ,
Sakoba Kéïta ,
Marie Paule Kieny ,
John-Arne Røttingen
August 2015
August 2015
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Abstract
A recombinant, replication-competent vesicular stomatitis virus-based vaccine expressing
a surface glycoprotein of Zaire Ebolavirus (rVSV-ZEBOV) is a promising Ebola vaccine
candidate. We report the results of an interim analysis of a trial of rVSV-ZEBOV in
Guinea, west Africa.