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Reduced peripheral activity leading to hepato-preferential action of basal insulin peglispro compared with insulin glargine in patients with type 1 diabetes.
S Mudaliar
1
,
2 ,
R R Henry
1
,
2 ,
T P Ciaraldi
1
,
2 ,
D A Armstrong
1 ,
P M Burke
1 ,
J H Pettus
2 ,
P Garhyan
3 ,
S L Choi
4 ,
M P Knadler
3 ,
E C Q Lam
4 ,
M J Prince
3 ,
N Bose
2 ,
N K Porksen
3 ,
V P Sinha
3 ,
H Linnebjerg
3 ,
S J Jacober
5
October 2016
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Abstract
Basal insulin peglispro (BIL), a novel PEGylated basal insulin with a large hydrodynamic size, has a delayed absorption and reduced clearance that prolongs the duration of action. The current study compared the effects of BIL and insulin glargine (GL) on endogenous glucose production (EGP), glucose disposal rate (GDR) and lipolysis in patients with type 1 diabetes.