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The Exploitation of Low-Energy Electrons in Cancer Treatment

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      Most cited references 188

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      Crystal structure of the nucleosome core particle at 2.8 A resolution.

      The X-ray crystal structure of the nucleosome core particle of chromatin shows in atomic detail how the histone protein octamer is assembled and how 146 base pairs of DNA are organized into a superhelix around it. Both histone/histone and histone/DNA interactions depend on the histone fold domains and additional, well ordered structure elements extending from this motif. Histone amino-terminal tails pass over and between the gyres of the DNA superhelix to contact neighbouring particles. The lack of uniformity between multiple histone/DNA-binding sites causes the DNA to deviate from ideal superhelix geometry.
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        The DNA-damage response in human biology and disease.

        The prime objective for every life form is to deliver its genetic material, intact and unchanged, to the next generation. This must be achieved despite constant assaults by endogenous and environmental agents on the DNA. To counter this threat, life has evolved several systems to detect DNA damage, signal its presence and mediate its repair. Such responses, which have an impact on a wide range of cellular events, are biologically significant because they prevent diverse human diseases. Our improving understanding of DNA-damage responses is providing new avenues for disease management.
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          Inelastic Collisions of Fast Charged Particles with Atoms and Molecules—The Bethe Theory Revisited

           MITIO INOKUTI (1971)
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            Author and article information

            Affiliations
            [1 ]Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Ontario Cancer Institute and Campbell Family Institute for Cancer Research and Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada
            Journal
            Radiation Research
            Radiation Research
            Radiation Research Society
            0033-7587
            1938-5404
            August 2017
            August 2017
            : 188
            : 2
            : 123-143
            10.1667/RR14727.1
            © 2017

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