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      Dynamic predictors of COVID-19 vaccination uptake and their interconnections over two years in Hong Kong

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          Abstract

          The global rollout of COVID-19 vaccines faces a significant barrier in the form of vaccine hesitancy. This study adopts a dynamic and network perspective to explore the determinants of COVID-19 vaccine uptake in Hong Kong, focusing on multi-level determinants and their interconnections. Following the framework proposed by the Strategic Advisory Group of Experts (SAGE), the study used repeated cross-sectional surveys to map these determinants at multiple levels and investigates their interconnections simultaneously in a sample of 15,179 over two years. The results highlight the dynamic nature of COVID-19 vaccine hesitancy in an evolving pandemic. The findings suggest that vaccine confidence attitudes play crucial roles in vaccination uptake, with their importance shifting over time. The initial emphasis on vaccine safety gradually transitioned to heightened consideration of vaccine effectiveness at a later stage. The study also highlights the impact of chronic condition, age, COVID-19 case numbers, and non-pharmaceutical preventive behaviours on vaccine uptake. Higher educational attainment and being married were associated with primary and booster vaccine uptake and it may be possible to leverage these groups as early innovation adopters. Trust in government acts as a crucial bridging factor linking various variables in the networks with vaccine confidence attitudes, which subsequently closely linked to vaccine uptake. This study provides insights for designing future effective vaccination programmes for changing circumstances.

          Abstract

          Understanding factors associated with COVID-19 vaccine uptake in an evolving pandemic context is important for future vaccine campaigns. Here, the authors investigate the main drivers of vaccine hesitancy in Hong Kong at different stages of the pandemic, where uptake was initially low despite high availability.

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          Vaccine hesitancy: Definition, scope and determinants.

          The SAGE Working Group on Vaccine Hesitancy concluded that vaccine hesitancy refers to delay in acceptance or refusal of vaccination despite availability of vaccination services. Vaccine hesitancy is complex and context specific, varying across time, place and vaccines. It is influenced by factors such as complacency, convenience and confidence. The Working Group retained the term 'vaccine' rather than 'vaccination' hesitancy, although the latter more correctly implies the broader range of immunization concerns, as vaccine hesitancy is the more commonly used term. While high levels of hesitancy lead to low vaccine demand, low levels of hesitancy do not necessarily mean high vaccine demand. The Vaccine Hesitancy Determinants Matrix displays the factors influencing the behavioral decision to accept, delay or reject some or all vaccines under three categories: contextual, individual and group, and vaccine/vaccination-specific influences.
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            qgraph: Network Visualizations of Relationships in Psychometric Data

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              Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine through 6 Months

              Background BNT162b2 is a lipid nanoparticle–formulated, nucleoside-modified RNA vaccine encoding a prefusion-stabilized, membrane-anchored severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) full-length spike protein. BNT162b2 is highly efficacious against coronavirus disease 2019 (Covid-19) and is currently approved, conditionally approved, or authorized for emergency use worldwide. At the time of initial authorization, data beyond 2 months after vaccination were unavailable. Methods In an ongoing, placebo-controlled, observer-blinded, multinational, pivotal efficacy trial, we randomly assigned 44,165 participants 16 years of age or older and 2264 participants 12 to 15 years of age to receive two 30-μg doses, at 21 days apart, of BNT162b2 or placebo. The trial end points were vaccine efficacy against laboratory-confirmed Covid-19 and safety, which were both evaluated through 6 months after vaccination. Results BNT162b2 continued to be safe and have an acceptable adverse-event profile. Few participants had adverse events leading to withdrawal from the trial. Vaccine efficacy against Covid-19 was 91.3% (95% confidence interval [CI], 89.0 to 93.2) through 6 months of follow-up among the participants without evidence of previous SARS-CoV-2 infection who could be evaluated. There was a gradual decline in vaccine efficacy. Vaccine efficacy of 86 to 100% was seen across countries and in populations with diverse ages, sexes, race or ethnic groups, and risk factors for Covid-19 among participants without evidence of previous infection with SARS-CoV-2. Vaccine efficacy against severe disease was 96.7% (95% CI, 80.3 to 99.9). In South Africa, where the SARS-CoV-2 variant of concern B.1.351 (or beta) was predominant, a vaccine efficacy of 100% (95% CI, 53.5 to 100) was observed. Conclusions Through 6 months of follow-up and despite a gradual decline in vaccine efficacy, BNT162b2 had a favorable safety profile and was highly efficacious in preventing Covid-19. (Funded by BioNTech and Pfizer; ClinicalTrials.gov number, NCT04368728 .)
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                Author and article information

                Contributors
                bcowling@hku.hk
                qyliao11@hku.hk
                Journal
                Nat Commun
                Nat Commun
                Nature Communications
                Nature Publishing Group UK (London )
                2041-1723
                4 January 2024
                4 January 2024
                2024
                : 15
                : 290
                Affiliations
                [1 ]School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, ( https://ror.org/02zhqgq86) Hong Kong, China
                [2 ]WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, ( https://ror.org/02zhqgq86) Hong Kong, China
                [3 ]Li Ka Shing Faculty of Medicine, Jocky Club Institute of Cancer Care, The University of Hong Kong, ( https://ror.org/02zhqgq86) Hong Kong, China
                [4 ]State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, ( https://ror.org/02zhqgq86) Hong Kong, China
                [5 ]Urban Systems Institute, The University of Hong Kong, ( https://ror.org/02zhqgq86) Hong Kong, China
                [6 ]Laboratory of Data Discovery for Health Limited, Hong Kong Science and Technology Park, New Territories, ( https://ror.org/02mbz1h25) Hong Kong, China
                Author information
                http://orcid.org/0000-0003-3429-8514
                http://orcid.org/0000-0002-1217-5858
                http://orcid.org/0000-0002-6297-7154
                http://orcid.org/0000-0002-1105-6857
                Article
                44650
                10.1038/s41467-023-44650-9
                10767005
                38177142
                883dbf11-c295-431a-8531-04e88dae7d90
                © The Author(s) 2024

                Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

                History
                : 4 September 2023
                : 20 December 2023
                Funding
                Funded by: FundRef https://doi.org/10.13039/501100005847, Food and Health Bureau of the Government of the Hong Kong Special Administrative Region | Health and Medical Research Fund (HMRF);
                Award ID: COVID19F04; COVID19F11
                Award Recipient :
                Funded by: Health and Medical Research Fund, the Health Bureau, The Government of the Hong Kong Special Administrative Region
                Categories
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                © Springer Nature Limited 2024

                Uncategorized
                decision making,public health,sars-cov-2,vaccines
                Uncategorized
                decision making, public health, sars-cov-2, vaccines

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