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Abstract
Studies with human volunteers and patients suffering from recurrent herpes simplex
virus (HSV) infections have shown that reinfections with autologous or heterologous
strains, occurring at sites distant from those of the recurrences, are possible in
a variable proportion of the subjects. Experiments in animals have shown that mice
surviving a primary HSV infection in the lumbo-sacral area, can become latently infected
in trigeminal ganglia upon reinfection of the orofacial site. Similar results were
obtained after vaccination of mice with a thymidine-kinase negative, non-pathogenic
HSV-1 mutant. It was also demonstrated that initial HSV-1 eye infection in rabbits
prevents superinfection of trigeminal ganglia by other strains.