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Non-alcoholic fatty liver disease, metabolic syndrome and patatin-like phospholipase domain-containing protein3 gene variants.

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      Abstract

      Non-alcoholic fatty liver disease was traditionally interpreted as a condition which may progress to liver-related complications. However, the increased mortality is primarily a result of cardiovascular diseases. It has been suggested that fatty liver can be considered as the hepatic consequence of the metabolic syndrome. The aim was to describe the different clinical presentations of non-alcoholic fatty liver disease on the basis of the patatin-like phospholipase domain-containing protein3 (PNPLA3) rs738409 gene variant.

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      Affiliations
      [1 ] Department of Internal Medicine and Medical Specialties, Sapienza University, Rome, Italy.
      [2 ] Department of Public Health and Infectious Disease, Sapienza University, Rome, Italy. Electronic address: francesco.angelico@uniroma1.it.
      Journal
      Eur. J. Intern. Med.
      European journal of internal medicine
      1879-0828
      0953-6205
      Jul 2014
      : 25
      : 6
      24947770
      S0953-6205(14)00148-4
      10.1016/j.ejim.2014.05.012
      Copyright © 2014 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.

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