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      Analysis of the correlation between MRI features and HER-2 expression inductal carcinoma in situ

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          Abstract

          Objective To investigate the correlation between the features of multimodal magnetic resonance imaging (MRI) and the expression of human epidermal growth factor receptor-2 (HER-2) in ductal carcinoma in situ (DCIS).

          Methods A total of 53 patients with DCIS confirmed by surgery and pathology in Dezhou Second People’s Hospital from September 2018 to June 2021 were analyzed retrospectively. The patients were divided into HER-2 positive group (29 cases) and HER-2 negative group (24 cases). MRI features were compared between the two groups.

          Results There were significant differences in the internal enhancement characteristics, microvascular sign, and time-intensity curve type between the two groups ( P < 0.05). There were no significant differences in lesion morphology, non-mass-like enhancement pattern, and apparent diffusion coefficient value ( P > 0.05). The HER-2 positive group showed clumped enhancement (65.5%), type I (48.1%) andtype I (29.6%) time-intensity curves, and microvascular sign (89.7%). The HER-2 negative group showed clusteredring enhancement (50.0%), type I (45.8%) and type I (54.2%) time-intensity curves, and microvascular sign (54.2%). A combination of clumped enhancement, microvascular sign, and type III time-intensity curve showed 100% specificity and 100% positive predictive value for the diagnosis of HER-2 positive DCIS.

          Conclusion Clumped enhancement, microvascular sign, and type I or I time-intensity curve on MRI can largely reflect the expression of HER-2 in DCIS. The three can be used in combination to improve the diagnostic efficiency of HER-2 positive DCIS.

          Abstract

          摘要: 目的 探讨乳腺导管内原位癌(DCIS)的MRI特征与HER-2表达的相关性。 方法 回顾性分析2018年9月一 2021年6月在德州市第二人民医院经手术病理证实的53例乳腺DCIS患者分为HER-2阳性组29例, HER-2阴性组 24例, 比较2组间MRI特征的差异。 结果 2组间内部强化特征、微血管征、TIC类型差异有统计学意义( P < 0.05); 病灶形态学、非肿块样强化分布形式、ADC值差异无统计学意义( P > 0.05)。HER-2阳性组以集群状强化(65.5%)为 主, TIC类型以II型(48.1%)、III型(29.6%)为主, 微血管征(89.7%); HER-2阴性组以簇环状强化(50.0%)为主, TIC类 型以II型(45.8%)、1型(54.2%)为主, 微血管征(54.2%);集群状强化, 微血管征、TIC III型3个参数同时具备诊断 HER-2阳性的特异度及阳性预测值均为100%。 结论 MRI参数中集群状强化、微血管征及TIC II型或III型曲线在 较大程度上能反映乳腺DCIS中HER-2表达情况, 三者联合应用可提高HER-2阳性的诊断效能。

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          Author and article information

          Journal
          CJRH
          Chinese Journal of Radiological Health
          Chinese Preventive Medical Association (Ji’an, China )
          1004-714X
          01 August 2022
          01 December 2022
          : 31
          : 4
          : 507-511
          Affiliations
          [1] 1Dezhou Second People’s Hospital, Medical Imaging Center, Dezhou 253004 China
          [2] 2Pathology Department, Dezhou 253004 China
          Author notes
          Corresponding author: SHAO Yuanwei, E-mail: dzeysyw@ 123456163.com
          Article
          j.issn.1004-714X.2022.04.024
          10.13491/j.issn.1004-714X.2022.04.024
          886682a5-f944-4e26-99d7-bd8132fbf8ee
          © 2022 Chinese Journal of Radiological Health

          This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 Unported License (CC BY-NC 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. See https://creativecommons.org/licenses/by-nc/4.0/.

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          Categories
          Journal Article

          Medicine,Image processing,Radiology & Imaging,Bioinformatics & Computational biology,Health & Social care,Public health
          Clumped enhancement,Ductal carcinoma in situ,MRI,Human epidermal growth factor receptor-2

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