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      Risks of chronicity following acute hepatitis B virus infection: a review.

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          Abstract

          A bibliographic search was conducted of English-language articles dealing with chronic hepatitis B virus (HBV) infection to evaluate the risk of chronicity following acute infection. Chronic HBV infection was defined as carriage of hepatitis B surface antigen (HBsAg) for at least 6 months. On the basis of incidence studies employing standard serological test methods, the highest risk (80%-90%) of chronic infection was found to be among infected neonates born to hepatitis B e antigen-positive carrier mothers. Of children infected before 6 years of age, chronic infection was reported to develop in approximately 30%. A relatively wide range of risks (< 1%-12%) was found among diverse populations of older children and adults. However, most of the 10 identified incidence studies of generally healthy adults indicated that the risk of chronicity is very low: < or = 5% in eight studies. In addition, the pooled incidence of chronicity was < 5% among two different adult population groups: initially uninfected subjects, who usually experienced asymptomatic infection, and patients presenting with acute hepatitis B. In addition to the primary influence of age, the studies revealed a higher risk of chronic HBV infection among males and among patients with impaired immunity due to various causes.

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          Author and article information

          Journal
          Clin Infect Dis
          Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
          Oxford University Press (OUP)
          1058-4838
          1058-4838
          Apr 1995
          : 20
          : 4
          Affiliations
          [1 ] Naval Medical Research Institute, Rockville, Maryland 20852, USA.
          Article
          10.1093/clinids/20.4.992
          7795104
          8866bc46-dd29-4e6b-8691-da533185726d
          History

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