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      Effect of γ-Glutamyl Carboxylation of Renal Microsomes on Calcium Oxalate MonohydrateCrystal Binding in Hyperoxaluria

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      Nephron

      S. Karger AG

      Carboxylation, Calcium oxalate monohydrate, Hyperoxaluria

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          Abstract

          Aim: The γ-carboxy glutamic acid (gla) containing proteins have been shown recently to have a role in calcium oxalate urolithiasis. Therefore, the effect of carboxylation on calcium oxalate monohydrate (COM) binding was studied in experimental hyperoxaluria. Methods: Urolithiasis was induced in experimental rats by oral feeding 1% ethylene glycol (EG). The microsomes were carboxylated in presence of reduced vitamin K and COM binding activity was determined. Results: Microsomal proteins adsorbed maximally with COM crystals. On carboxylation of the renal microsomal proteins, a significant increase in the COM crystal adsorption by 2.5-fold (p < 0.001) was observed in the hyperoxaluric condition. Further cyboxylated microsomes of EG-treated rats showed significant binding with calcium oxalate. Conclusion: This study presents an increased COM adsorption after the carboxylation of renal microsomes of hyperoxaluric rats.

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          Most cited references 3

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          Contactless growth of ZnSe single crystals by physical vapor transport

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            Determination of protein-bound urinary gamma-carboxyglutamic acid in calcium nephrolithiasis

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              Enhanced Renal Vitamin-K- Dependent Gamma-Glutamyl Carboxylase Activity in Experimental Rat Urolithiasis

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                Author and article information

                Journal
                NEF
                Nephron
                10.1159/issn.1660-8151
                Nephron
                S. Karger AG
                1660-8151
                2235-3186
                1999
                March 1999
                26 February 1999
                : 81
                : 3
                : 342-346
                Affiliations
                Department of Medical Biochemistry, Dr. ALM Post-Graduate Institute of Basic Medical Sciences, University of Madras, Taramani, India
                Article
                45303 Nephron 1999;81:342–346
                10.1159/000045303
                10050091
                © 1999 S. Karger AG, Basel

                Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

                Page count
                Figures: 1, Tables: 3, References: 26, Pages: 5
                Product
                Self URI (application/pdf): https://www.karger.com/Article/Pdf/45303
                Categories
                Original Paper

                Cardiovascular Medicine, Nephrology

                Hyperoxaluria, Calcium oxalate monohydrate, Carboxylation

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