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      Tear Nitrite and Nitrate Levels as Nitric Oxide End Products in Patients with Behçet’s Disease and Non-Behçet’s Uveitis

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          To evaluate the role of nitric oxide (NO) in ocular inflammation, tear nitrite and nitrates (NN) as NO end products were determined in 11 patients with Behçet’s disease (BD) and in 11 with non-Behçet’s uveitis (NBU) during the active and remission stages and in 12 healthy controls. Median (with the range) NN levels were 82.29 (59.60–98.25) µmol/l in the active and 98.25 (52.88–246.92) µmol/l in the remission stage of BD; 88.17 (25.99–116.73) µmol/l in the active and 83.00 (31.04–250.28) µmol/l in the remission stage of NBU and 109.17 (88.17–158.74) µmol/l in the controls. The NN levels in the active stage of BD and NBU were significantly decreased when compared to the controls (p < 0.05; Kruskal-Wallis test). Decreased NN levels at the activation stage may be caused by the rapid transformation of the NO to peroxynitrites, which are highly oxidizing and cytotoxic substances.

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          Criteria for diagnosis of Behcet's disease

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            Effects of nitric oxide synthase inhibitor on intraocular pressure and ocular inflammation following laser irradiation in rabbits.

            To examine the effects of nitric oxide synthase (NOS) inhibitors on intraocular pressure (IOP) and ocular inflammation following laser irradiation of the rabbit iris, and to investigate the involvement of nitric oxide (NO). Thirty min after the intravenous administration of a nonselective inhibitor of NOS, N omega-nitro-L-arginine methyl ester (L-NAME, 1-100 mg/kg), or a selective inhibitor of iNOS, aminoguanidine (AG, 100 mg/kg), Q-switched Nd:YAG laser irradiation was applied to the iris of albino rabbits at an energy level of 48 mJ. IOP was measured prior to and for 24 h after irradiation. In separate groups of rabbits, aqueous humor was withdrawn 30 min after irradiation to determine protein and prostaglandin (PG) E2 concentrations. Intravenously administered L-NAME dose-dependently inhibited the acute increase in IOP, the peak of which was observed at 30 min, following laser irradiation. The IOP increase was completely abolished by 100 mg/kg of L-NAME. This dose of L-NAME significantly reduced the elevation of protein concentration in aqueous humor following irradiation; however, this dose failed to affect the increase in PGE2 concentration On the other hand, the inhibitory effects of AG (100 mg/kg) on the increase in IOP and aqueous protein following laser irradiation were not significant. Intravenous administration of L-NAME significantly inhibits the IOP rise and the increase in protein concentration in aqueous humor following laser irradiation, but AG does not, suggest the involvement of cNOS in these ocular responses to laser irradiation.

              Author and article information

              Ophthalmic Res
              Ophthalmic Research
              S. Karger AG
              February 2001
              13 December 2000
              : 33
              : 1
              : 48-51
              Departments of aOphthalmology and bBiochemistry, Faculty of Medicine, Erciyes University, Kayseri, Turkey
              55641 Ophthalmic Res 2001;33:48–51
              © 2001 S. Karger AG, Basel

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              Page count
              Tables: 2, References: 9, Pages: 4
              Original Paper

              Vision sciences, Ophthalmology & Optometry, Pathology

              Tears, Nitrate, Nitrite, Nitric oxide, Behçet’s disease


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