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      Bromelain Loading and Release from a Hydrogel Formulated Using Alginate and Arabic Gum.

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          Abstract

          An ideal wound dressing ensures a moist environment around the wound area and absorbs exudates from the wound surface. Topical application of bromelain to incised wounds has been shown to reprogram the wound microenvironment to promote effective tissue repair. Combining the characteristics of hydrogels and bromelain is therefore of great interest. Herein, we describe the development of a hydrogel, formulated using alginate and Arabic gum, for bromelain loading and release. The hydrogel formulation was evaluated using response surface methodology, considering the pH value and the concentration of alginate and Arabic gum. Bromelain loading and release were evaluated based on passive diffusion. Differential scanning calorimetry and Fourier transform infrared spectroscopy were performed to confirm bromelain immobilization in the hydrogel. The final hydrogel formulation had a swelling ratio of 227 % and incorporated 19 % of bromelain from a bromelain solution. Bromelain immobilization in the hydrogel was the result of hydrogen bond formation and was optimal at 4 °C after 4 h of contact. This evidence suggests that bromelain entrapment into a hydrogel is a promising strategy for the development of wound dressings that support the debridement of burns and wounds.

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          Author and article information

          Journal
          Planta Med.
          Planta medica
          Georg Thieme Verlag KG
          1439-0221
          0032-0943
          Jul 2017
          : 83
          : 10
          Affiliations
          [1 ] Postgraduate Program in Medical Sciences, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, Brazil.
          [2 ] Postgraduate Program in Biosciences and Technology of Bioactive Products, Institute of Biology, State University of Campinas (UNICAMP), Campinas, Brazil.
          [3 ] Laboratory of Biomaterials & Nanotechnology, Universidade de Sorocaba (UNISO), Sorocaba, Brazil.
          [4 ] Faculty of Pharmaceutical Sciences, State University of Campinas (UNICAMP), Campinas, Brazil.
          [5 ] Chemical Engineering Systems Department, School of Chemical Engineering, State University of Campinas (UNICAMP), Campinas, Brazil.
          [6 ] Department of Technological and Environmental Processes, Universidade de Sorocaba (UNISO), Sorocaba, Brazil.
          [7 ] Genetics and Biochemistry Institute, Uberlandia Federal University (UFU), Uberlandia, Brazil.
          [8 ] College of Pharmacy, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.
          Article
          10.1055/s-0043-102948
          28196382
          887d0709-27db-4e5c-bc0f-d0f5a9b51be2
          History

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