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      Nogo and axon regeneration.

      Current Opinion in Neurobiology
      Animals, Axons, metabolism, physiology, Humans, Myelin Proteins, genetics, Nerve Regeneration

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          Abstract

          Nogo-A is one of several neurite growth inhibitory components present in oligodendrocytes and CNS myelin membranes. Nogo has a crucial role in restricting axonal regeneration and compensatory fibre growth in the injured adult mammalian CNS. Recent studies have shown that in vivo applications of Nogo neutralizing antibodies, peptides blocking the Nogo receptor subunit NgR, or blockers of the postreceptor components Rho-A and ROCK induce long-distance axonal regeneration and compensatory sprouting, accompanied by an impressive enhancement of functional recovery, in the rat and mouse spinal cord.

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          Author and article information

          Journal
          15018947
          10.1016/j.conb.2004.01.004

          Animals,Axons,metabolism,physiology,Humans,Myelin Proteins,genetics,Nerve Regeneration

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