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      Dendritic cells directly trigger NK cell functions: cross-talk relevant in innate anti-tumor immune responses in vivo.

      Nature medicine

      Adoptive Transfer, Animals, Cell Communication, Coculture Techniques, Cytotoxicity, Immunologic, DNA-Binding Proteins, Dendritic Cells, immunology, Killer Cells, Natural, Ligands, Lymphocyte Activation, Major Histocompatibility Complex, Membrane Proteins, Mice, Mice, Inbred Strains, Mice, Mutant Strains, Neoplasms, Experimental, classification

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          Abstract

          Cytotoxic T lymphocytes and natural killer cells are essential effectors of anti-tumor immune responses in vivo. Dendritic cells (DC) 'prime' tumor antigen-specific cytotoxic T lymphocytes; thus, we investigated whether DC might also trigger the innate, NK cell-mediated anti-tumor immunity. In mice with MHC class I-negative tumors, adoptively transferred- or Flt3 ligand-expanded DC promoted NK cell-dependent anti-tumor effects. In vitro studies demonstrated a cell-to-cell contact between DC and resting NK cells that resulted in a substantial increase in both NK cell cytolytic activity and IFN-gamma production. Thus, DC are involved in the interaction between innate and adaptive immune responses.

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          Journal
          10202929
          10.1038/7403

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