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      Evaluation of oxygen extraction fraction in systemic lupus erythematosus patients using quantitative susceptibility mapping

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          Abstract

          The purposes of this study are to assess the oxygen extraction fraction (OEF) changes on MRI-based quantitative susceptibility mapping (QSM) in systemic lupus erythematosus (SLE) patients and to determine whether QSM-OEF is associated with disease activity in SLE. We enrolled 42 SLE patients and 20 healthy subjects (HS) who had no pathologies on conventional brain MRI. Disease activity was assessed using SLE Disease Activity Index (SLEDAI). For the measurement of QSM-OEF, QSM data were analysed using the Perfusion Mismatch Analyzer software program. Spearman's or Pearson's correlation coefficients were calculated, and independent predictors were identified through a multiple linear regression analysis. QSM-OEF was significantly higher in SLE than that in HS (51.3 ± 10.1 vs. 40.5 ± 3.7, p < 0.001). QSM-OEF was positively correlated with SLEDAI and the presence of neuropsychiatric symptom (NPS) scores (ρ = 0.663, p < 0.001 and ρ = 0.340, p = 0.028). At multiple linear regression analysis, SLEDAI and NPS were independently associated with QSM-OEF (standardized β = 0.426, p = 0.016 and standardized β = 6.148, p = 0.029). In the SLE patients, QSM-OEF is associated with disease activity, which might predict an increased risk of stroke in SLE.

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          Author and article information

          Journal
          J Cereb Blood Flow Metab
          J. Cereb. Blood Flow Metab
          JCB
          spjcb
          Journal of Cerebral Blood Flow & Metabolism
          SAGE Publications (Sage UK: London, England )
          0271-678X
          1559-7016
          16 March 2018
          August 2019
          : 39
          : 8
          : 1648-1658
          Affiliations
          [1 ]Department of Radiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
          [2 ]Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan
          [3 ]Department of the First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
          [4 ]Departments of Biomedical Engineering and Radiology, Cornell University, MedImageMetric LLC, New York, NY, USA
          Author notes
          [*]Shingo Kakeda, Department of Radiology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, Fukuoka 807-8555, Japan. Email: kakeda@ 123456med.uoeh-u.ac.jp
          Article
          PMC6681530 PMC6681530 6681530 10.1177_0271678X18764829
          10.1177/0271678X18764829
          6681530
          29547080
          889e4723-405e-4223-bdd1-d060b56e5ae9
          © The Author(s) 2018
          History
          : 7 November 2017
          : 30 January 2018
          : 12 February 2018
          Categories
          Original Articles

          perfusion mismatch analyzer,oxygen extraction fraction,misery perfusion,quantitative susceptibility mapping,Systemic lupus erythematosus

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